SYSTEMATIC REVIEW article
Front. Nephrol.
Sec. Clinical Research in Nephrology
Volume 5 - 2025 | doi: 10.3389/fneph.2025.1630718
Impact of Chronic Kidney Disease on Health-Related Quality of Life in Adults: A Systematic Review and Meta-Analysis Protocol
Provisionally accepted
William Wilberforce Amoah1,2*
William Wilberforce Amoah3*Chikaodili Ihudiebube-Splendor2
Victor Luckyboy Dzramado3,4- 1Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
- 2Uniersity of Nigeria, Nsukka, Nsukka, Nigeria
- 3kwame Nkrumah University of Science and Technology, Kumasi, Ghana
- 4Cape Coast Teaching Hospital, Cape Coast Ghana, Cape Coast, Ghana
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Introduction: Chronic Kidney Disease (CKD) significantly impacts patients' health-related quality of life (HRQoL), yet comprehensive evidence synthesis remains limited, particularly from African contexts. This systematic review aims to evaluate how CKD affects HRQoL in adult patients and identify the most impacted domains across disease stages, providing evidence to guide patient-centered care and health policy. Methods: Following PRISMA-P 2020 guidelines, we will systematically search PubMed, Embase, Scopus, Web of Science, Cochrane Library, and grey literature for observational studies and clinical trials evaluating HRQoL in adults (≥18 years) with CKD using validated instruments (SF-36, KDQOL, EQ-5D). Two independent reviewers will conduct study selection, data extraction, and quality assessment using the Newcastle-Ottawa Scale and Cochrane Risk of Bias Tool. Meta-analysis will be performed where feasible, with subgroup analyses by CKD stage, treatment modality, and geographic region. Expected Outcomes: This review will provide nurses and clinicians with comprehensive evidence on HRQoL impairments across CKD stages, inform development of targeted psychosocial interventions, and guide resource allocation for holistic patient care. Findings will support healthcare providers in addressing not only physiological parameters but also patients' subjective wellbeing and quality of life.
Keywords: Chronic Kidney Disease, Health-related Quality of Life (HR QoL) outcomes, impact, Hypertension, Mortality
Received: 18 May 2025; Accepted: 15 Oct 2025.
Copyright: © 2025 Amoah, Amoah, Ihudiebube-Splendor and Dzramado. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
William Wilberforce Amoah, williamamoah481@gmail.com
William Wilberforce Amoah, williamamoah481@gmail.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.