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MINI REVIEW article

Front. Nephrol.

Sec. Blood Purification

Volume 5 - 2025 | doi: 10.3389/fneph.2025.1647025

This article is part of the Research TopicExtracorporeal Organ Support: Innovations and Challenges in Critical CareView all 3 articles

Hemoadsorption: A New Tool in Neurotoxic Poisoning

Provisionally accepted
Hernandez-Vaquero,  JHernandez-Vaquero, J1*Repilado-Alvarez  ARepilado-Alvarez A2de la Flor  JCde la Flor JC1Mata Forte  TMata Forte T1
  • 1Hospital Central de la Defensa Gomez Ulla, Madrid, Spain
  • 2Gobierno de Espana Ministerio de Defensa, Madrid, Spain

The final, formatted version of the article will be published soon.

Although the use of neurotoxic agents as weapons of war (CWAs) or in terrorist attacks is relatively uncommon, it has been documented on several occasions in recent history, including the Syrian civil war, the Tokyo subway attack, and the Salisbury incident. The toxidrome associated with these agents is well described; however, treatment remains largely supportive, as effective antidotes are not currently available. Conventional renal replacement therapies (RRT), such as hemodialysis or continuous modalities, are not recommended for managing neurotoxic agent poisoning due to their toxicodynamic properties. In contrast, hemoadsorption (HA), especially when combined with CRRT, has shown promise in organophosphate (OP) pesticide poisonings. Given the chemical similarities between neurotoxic CWAs and OP, HA may represent a rational therapeutic option in selected cases.

Keywords: Hemoperfusion, Chemical Warfare Agents, Pesticides/poisoning, Renal Replacement Therapy, Organophosphate Poisoning

Received: 14 Jun 2025; Accepted: 25 Aug 2025.

Copyright: © 2025 J, A, JC and T. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Hernandez-Vaquero, J, Hospital Central de la Defensa Gomez Ulla, Madrid, Spain

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