CASE REPORT article
Front. Nephrol.
Sec. Glomerular disease
Volume 5 - 2025 | doi: 10.3389/fneph.2025.1667619
Exostosin 1-associated Membranous nephropathy and Guillain-Barré syndrome: a common autoimmune etiology?
Provisionally accepted
Mariana León-Póo1Eva López-Melero1
Amir Shabaka2*Carmen Guerrero-Márquez1María Barcenilla-López3Clara Cases-Corona1Enrique Gruss1Deborah Roldán1- 1Hospital Universitario Fundacion Alcorcon, Alcorcón, Spain
- 2Hospital Universitario La Paz, Madrid, Spain
- 3Hospital Universitario de Fuenlabrada, Fuenlabrada, Spain
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Membranous nephropathy is one of the most common causes of nephrotic syndrome in adults and is caused by the deposition of immune complexes in the subepithelial space of the glomerular basement membranes. On the other hand, Guillain-Barré syndrome is a type of acute, potentially fatal polyneuropathy, which is generally associated with an infection that serves as the initial immunological event and triggers immune-mediated disruption of the axon and/or myelin. We present the case of a 70-year-old patient with concurrent membranous nephropathy and Guillain-Barré syndrome, with subepithelial deposits in the renal biopsy positive for Exostosin 1, and who reached complete renal remission after treatment of Guillain-Barré syndrome with plasmapheresis and systemic corticosteroids, suggesting a common autoimmune origin for both entities.
Keywords: Nephrotic Syndrome, Demyelinating polyneuropathy, Contactin, Exostosin 1, immunology
Received: 16 Jul 2025; Accepted: 15 Sep 2025.
Copyright: © 2025 León-Póo, López-Melero, Shabaka, Guerrero-Márquez, Barcenilla-López, Cases-Corona, Gruss and Roldán. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Amir Shabaka, amirshabaka@hotmail.com
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