CASE REPORT article
Front. Nucl. Med.
Sec. PET and SPECT
Volume 5 - 2025 | doi: 10.3389/fnume.2025.1693642
This article is part of the Research TopicMusculoskeletal Disorders Related to DysparathyroidismView all 6 articles
18F-Fluorocholine PET/CT for detecting brown tumours in patients with hyperparathyroidism: a short case series and literature review
Provisionally accepted
- 1Clinique Sud Luxembourg, Vivalia, Arlon, Belgium
- 2Nuclear Medicine, Theageneio Cancer Center, Thessaloniki, Greece
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Introduction: Brown tumours (BTs), also known as osteitis fibrosa cystica, are benign osteolytic lesions associated with hyperparathyroidism (HPT). BTs are cured by correcting the hypercalcaemia and HPT, which often requires surgical resection of the parathyroid adenoma. ¹⁸F-fluorocholine (FCH) PET/CT is becoming an effective tool for detecting parathyroid adenomas in cases of hyperparathyroidism. This study aims to evaluate the role of FCH PET/CT in detecting brown tumours in patients with hyperparathyroidism. Clinical cases Three cases are presented to demonstrate the effectiveness of FCH PET/CT in detecting BTs in patients presenting with clinical and biochemical signs of HPT with suspicion of BTs. Literature review: A literature review aimed to summarize the bibliographic evidence on the use of this technique in this setting, which is relatively innovative. Conclusion: FCH PET/CT appears to be a useful tool for detecting BTs, and further prospective studies are needed to confirm this.
Keywords: 18F-Fluorocholine PET/CT, brown tumours, Hyperparathyroidism, osteolytic bone destruction, Parathyroid adenoma
Received: 27 Aug 2025; Accepted: 22 Oct 2025.
Copyright: © 2025 ZHANG-YIN and Panagiotidis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jules ZHANG-YIN, tianyuzhang777@msn.com
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