MINI REVIEW article
Front. Nucl. Med.
Sec. Radionuclide Therapy
Recent clinical advances in fibroblast activation protein targeted radioligand therapy for solid tumors
Provisionally accepted
- 1Sichuan University, Chengdu, China
- 2Air Force Hospital Medical Service Department in Western Theatre, Chengdu, China
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Fibroblast activation protein (FAP) is a type II transmembrane serine protease predominantly expressed by cancer-associated fibroblasts (CAFs) in more than 90% of epithelial malignancies. The advent of FAP inhibitor (FAPI)-based positron emission tomography (PET) imaging has established FAP as a promising pan-tumor target for radioligand therapy (RLT). This review summarizes the current clinical landscape of FAP-targeted RLT in solid tumors, while also discussing existing challenges and future directions in this rapidly evolving field.
Keywords: fibroblast activation protein, FAP, FAP inhibitor, FAPI, Radioligand Therapy, solid tumors
Received: 01 Nov 2025; Accepted: 24 Nov 2025.
Copyright: © 2025 Wu, Wang, Li and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wenli Hu
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