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SYSTEMATIC REVIEW article

Front. Physiol.
Sec. Vascular Physiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1368892

Effect of blueberry intervention on endothelial function: A systematic review and meta-analysis

Provisionally accepted
Bixin Deng Bixin Deng 1Yupeng Lei Yupeng Lei 2Ruixi Zhou Ruixi Zhou 2,3Tiechao Ruan Tiechao Ruan 4Wenting Lu Wenting Lu 5Junjie Ying Junjie Ying 3Yan Yue Yan Yue 4*Dezhi Mu Dezhi Mu 6,7*
  • 1 Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 2 Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 3 Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 4 Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China, chengdu, China
  • 5 Integrated Care Management Center, West China Hospital, Sichuan University, Chengdu, China, chendu, China
  • 6 West China Second University Hospital, Sichuan University, Chengdu, China
  • 7 Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Endothelial dysfunction indicates blood vessel injury and is a risk factor for cardiovascular diseases. Blueberry has been approved for its benefits on human health, especially on cardiovascular function. However, its effect on endothelial function remains unclear. We conducted a systematic review and meta-analysis to explore the impact of blueberries on endothelial function in adults. After searching PubMed, Web of Science, Embase, and the Cochrane Library, 16 studies were included in the systematic review, and 11 were used for the meta-analysis. Data associated with endothelial function were extracted and pooled as mean differences (MD) with 95% confidence intervals (CI). Blueberry consumption significantly improved flow-mediated dilation (FMD) by 1.50% (95% CI: 0.81, 2.20; I2 = 87%) and reactive hyperemia index (RHI) by 0.26 (95% CI: 0.09, 0.42; I2 = 72%). A significant decrease in diastolic blood pressure (DBP) was also observed (MD:

    Keywords: Endothelial dysfunction, blueberry, blood pressure, review, metaanalysis -2.20 mm Hg, 95% CI: -4.13, -0.27, I2 = 11%). Subgroup analysis indicated a significant decrease in blood pressure (Systolic blood pressure [SBP]: -3.92 mmHg, 95% CI: -6.88, -0.97, I2 = 20% and DBP: -2.20 mmHg, I2 = 11%) in the smoking population. However, SBP levels (MD: -1.43 mm Hg, 95% CI: -3.11, 0.26, I2 = 20%) and lipid status (high-density lipoprotein cholesterol [HDL-C]: 0.06

    Received: 03 Feb 2024; Accepted: 15 May 2024.

    Copyright: © 2024 Deng, Lei, Zhou, Ruan, Lu, Ying, Yue and Mu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yan Yue, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China, chengdu, China
    Dezhi Mu, West China Second University Hospital, Sichuan University, Chengdu, China

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