REVIEW article

Front. Physiol.

Sec. Skeletal Physiology

Volume 16 - 2025 | doi: 10.3389/fphys.2025.1527814

TNF receptor-associated factors (TRAFs): Promising Targets of Natural Products for the Treatment of Osteoporosis

Provisionally accepted
XiCheng  YangXiCheng Yang1Lili  ZhaoLili Zhao2*YinQuan  PangYinQuan Pang3
  • 1Hebei Medical University, Shijiazhuang, Hebei Province, China
  • 2Xingtai City People's Hospital, Xingtai, China
  • 3Graduate School, Chengde Medical University, Chengde, Shanghai Municipality, China

The final, formatted version of the article will be published soon.

Tumor necrosis factor receptor-associated factors (TRAFs) are crucial intracellular signaling proteins in bone homeostasis. TRAFs mediate pathways associated with bone remodeling, particularly in response to inflammatory stimuli, influencing osteoclast differentiation and function. Dysregulation of TRAF-mediated signaling contributes significantly to osteoporosis, a condition marked by increased bone resorption and fragility. Natural products, with their anti-inflammatory and antioxidant properties, offer promising therapeutic potential by targeting TRAF-associated pathways to inhibit excessive osteoclast activity and promote bone formation. This review explores the mechanisms by which natural compounds modulate TRAF signaling in osteoclastogenesis and osteoblastogenesis, providing insights into their potential for osteoporosis treatment.

Keywords: common genes, such as SNAP25, AQP4, SV2B, KCND3, ABCA2, CD163, CD14

Received: 15 Nov 2024; Accepted: 07 Mar 2025.

Copyright: © 2025 Yang, Zhao and Pang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Lili Zhao, Xingtai City People's Hospital, Xingtai, China

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