REVIEW article
Front. Physiol.
Sec. Cell Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1553646
The Advances in Acetylation Modification in Senescence and Aging-related Diseases
Provisionally accepted
Pengbo Wang1,2*
Sicong Chen2Maiqi Xu2
Wenbin Wang2Saien Lu2Mengyao Xiong2Tong Zhao2Yao Yu2Chunyu Song3Jinjing Yang2
Naijin Zhang3Liu Cao2
Guozhe Sun2- 1China Medical University, Shenyang, China
- 2The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
- 3The Cadre Department, The First Hospital of China Medical University, Shenyang, Liaoning Province, China
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Aging is a process in which organisms or cells undergo a decline in their functions.Epigenetic modification changes have been recognized as a senescence hallmark in both natural aging and stimulation-induced senescence. An acetylation modification is a dynamic process, which plays a crucial role in the senescence process through DNA stability, metabolism, and signaling pathways. We summarized the role and regulatory pathways of acetylation modifications in senescence. Various cell fate-determining proteins regulate multiple cellular processes through acetylation modifications. These processes interact and coordinate with each other, forming an integrated regulatory network framework that collectively drives cellular senescence via multiple systemic mechanisms. Based on these findings, we proposed the "acetylation-network regulation-cellular senescence" model, to elaborate how acetylation contributes to senescence. We believe this insight could provide new directions and intervention strategies for senescence and aging-related diseases.
Keywords: Acetylation modification, Aging, DNA stability, Mitochondrial function, Network Mechanism, Protein homeostasis
Received: 31 Dec 2024; Accepted: 28 Apr 2025.
Copyright: © 2025 Wang, Chen, Xu, Wang, Lu, Xiong, Zhao, Yu, Song, Yang, Zhang, Cao and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Pengbo Wang, China Medical University, Shenyang, China
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