SYSTEMATIC REVIEW article
Front. Physiol.
Sec. Skin Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1556998
Efficacy of Probiotics in Dermatitis Herpetiformis Management: An Umbrella Review
Provisionally accepted
Waleed Khalid Alghuyaythat1,2*
Fawziah Salman Alfaifi3
Hind Bader S Alshalhoob2Rana Khalid A Abanumay2Rayan Hussain A Asiree2Haya Sulaiman Alnumayr4Anwar Ghudair T Alanazi2Maryam Mohammed Alluli2- 1Majmaah University, Al Majma'ah, Saudi Arabia
- 2College of Medicine, Majmaah University, 11952, Majmaah, Saudi Arabia, Majmaah, Saudi Arabia
- 3Department of Dermatology, King Faisal Medical City for Southern Region (KFMC), Abha, Saudi Arabia, Abha, Saudi Arabia
- 4College of Medicine, Qassim University, Qassim, Saudi Arabia
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Background-The available evidence on probiotics in Dermatitis Herpetiformis (DH) remains severely limited. Given the shared pathophysiology of DH and Coeliac disease (CD), we aimed to provide the hypothesis to synthesize the narrative reviews carried out so far on the use of probiotics in the treatment of DH, its impact on gut microbiota dysbiosis, and the gut-skin axis.Methods: Relevant narrative reviews were searched for in electronic databases such as PubMed, Scopus, Cochrane Library, Embase, and Google Scholar.Results: All 7 included reviews commented on gut microbiota dysbiosis as a common feature in patients with CD and DH. Immune modulation, attenuation of intestinal permeability, and anti-inflammatory effects were some of the postulated effects of probiotics. Probiotics could modulate the gut-skin axis and may prove therapeutic for DH; however, most of the evidence was indirect, drawn from models of CD or theoretically derived.While probiotics showed promise for managing gut dysbiosis and immune regulation in DH, the existing evidence remains speculative. Our results suggest that probiotics could be a useful adjunct to gluten-free dieting in DH treatment, but future studies are needed to support this finding.
Keywords: Dermatitis Herpetiformis, Probiotics, Gut Microbiota, Immune Modulation, Skin health
Received: 07 Jan 2025; Accepted: 02 Apr 2025.
Copyright: © 2025 Alghuyaythat, Alfaifi, Alshalhoob, Abanumay, Asiree, Alnumayr, Alanazi and Alluli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Waleed Khalid Alghuyaythat, Majmaah University, Al Majma'ah, Saudi Arabia
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.