REVIEW article
Front. Physiol.
Sec. Lipid and Fatty Acid Research
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1584195
This article is part of the Research TopicThe Evolving Landscape of Lipid Mediators: Insights into Physiology and Cell SignalingView all 6 articles
Effects of Molecular Interactions Between the Exposome and Oxylipin Metabolism on Healthspan
Provisionally accepted
- 1Department of Chemistry, College of Natural Science, Michigan State University, East Lansing, Michigan, United States
- 2Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, United States
- 3Department of Pharmacology and Toxicology, Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, East Leansing, Michigan, United States
- 4Michigan State University, East Lansing, United States
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While aging is typically synonymous with the lifespan of an individual, the healthspan, or the total number of years an individual remains healthy and disease-free, is not necessarily related. A current, critical need in society has arisen as current populations are living longer than previous generations, thus increasing the number of people with age-associated diseases. However, the extent of all age mechanisms is not entirely known. Still, studies examining how the exposome, or an individual’s cumulative exposures throughout their life, can influence or modulate aging processes will strengthen our understanding of how to keep individuals healthy and disease-free longer, bridging the gap between lifespan and healthspan. In contrast, previous research has also demonstrated that the exposome impacts aging. One subcategory of the exposome, the specific external, encompasses daily exposures such as diet, lifestyle factors, and occupational and environmental exposures. In this review, we focus on the interactions between factors of the exposome, such as vitamins and minerals, and their effects on aging, cell death, cellular senescence, and unsaturated fatty acid metabolism. We also discuss the interaction between oxidative fatty acid metabolism and aging itself. Overall, understanding how various exposures impact both the oxylipin profile and healthy aging will inform future interventions aimed at improving the healthspan and quality of life for this large aging population.
Keywords: Scenescence, molecular mechainsm, Aging, Oxylipin, Metabolism
Received: 27 Feb 2025; Accepted: 21 May 2025.
Copyright: © 2025 Hinman, Alan and Lee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Kin Sing Stephen Lee, Michigan State University, East Lansing, United States
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