SYSTEMATIC REVIEW article
Front. Physiol.
Sec. Craniofacial Biology and Dental Research
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1593204
Clinical effects of erythritol,glycine and trehalose as subgingival air-polishing powders on non-surgical periodontal treatment:a systematic review with metaanalysis of randomized controlled trials
Provisionally accepted
- 1Changsha Stomatological Hospital, Changsha, China
- 2Xiangya School of Stomatology, Central South University, Changsha, Hunan Province, China
- 3Orthodontics, Xiangya Stomatological Hospital, Changsha, China
- 4Periodontics, Xiangya Stomatological Hospital, Changsha, China
- 5Periodontology and Oral Mucosa, Changsha Stomatological Hospital, Changsha, China
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PURPOSE: This study aimed to systematically compare the efficacy of erythritol, glycine, and trehalose as subgingival subgingival air polishing powders in non-surgical periodontal treatment (NSPT). METHODS: Randomized controlled trials (RCTs) that met the inclusion and exclusion criteria were selected from PubMed, Embase, Web of Science, and Cochrane Library databases (up to August 2024). The sample size, treatment time, and outcome indicators including periodontal probing depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP) were extracted from the articles. Direct meta-analysis and network meta-analysis wereThe recommended order of priority for the use of three subgingival subgingival air polishing powders is as follows: erythritol, trehalose, and glycine.Strenaths and limitaions of this study:We recommend the priority for the use of the three powders was as follows: erythritol, trehalose, and glycine.Limitations:limited number of RCTs made it difficult to draw a test for publication bias.
Keywords: Subgingival Air-polishing, Non-surgical periodontal treatment, Erythritol, Glycine, Trehalose
Received: 13 Mar 2025; Accepted: 17 Jul 2025.
Copyright: © 2025 Zi-Le, Tang, Zhou, Li, Chen and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Meilu Zhou, Periodontology and Oral Mucosa, Changsha Stomatological Hospital, Changsha, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.