SYSTEMATIC REVIEW article
Front. Physiol.
Sec. Skeletal Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1598514
Platelet rich plasma injections for knee osteoarthritis: an overview of systematic reviews
Provisionally accepted
- 1The First Affiliated Hospital of Hunan University of Medicine, Huaihua, China
- 2Hunan Primary Digital Engineering Technology Research Center for Medical Prevention and Treatment, Huaihua, China
- 3Hunan University of Chinese Medicine, Changsha, Anhui Province, China
- 4Hunan Engineering Research Center of TCM Real-World Clinical Practice, huaihua, China
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Knee osteoarthritis (KOA) is a common degenerative joint disorder, especially among the aging population. Multiple systematic reviews (SRs) and meta-analyses (MAs) have investigated the therapeutic effectiveness and safety profile of platelet-rich plasma (PRP) in managing KOA. This overview aims to systematically assess the methodological rigor, potential bias, and reporting standards of existing SRs/MAs concerning PRP interventions for KOA. Comprehensive searches were conducted in PubMed, Embase, The Cochrane Library, and Web of Science from inception to December 1, 2024, to identify relevant SRs/MAs. Two reviewers independently performed literature screening and data extraction. Methodological quality, study overlap and risk of bias were evaluated using AMSTAR2, GROOVE tools and ROB2.0 tools. A total of 29 SRs/MAs met the inclusion criteria. The GROOVE found that there was a very high overlap among the included articles. The results of the AMSTAR2 assessment showed that the methodological quality of 26 reviews was assessed as critically low quality, and 3 reviews were rated low. Overall, the current quality of SRs/MAs on PRP for KOA remains suboptimal. Future studies should adhere closely to established evaluation frameworks including AMSTAR2 to enhance research reliability and clinical applicability.
Keywords: Platelet-Rich Plasma, knee osteoarthritis, AMSTAR2, groove, ROB
Received: 23 Mar 2025; Accepted: 20 Jun 2025.
Copyright: © 2025 Yi, qiu, song, huang and zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: fei qiu, The First Affiliated Hospital of Hunan University of Medicine, Huaihua, China
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