ORIGINAL RESEARCH article
Front. Physiol.
Sec. Cell Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1607873
Mechanisms of Skeletal Muscle Atrophy in Type 2 Diabetes Mellitus
Provisionally accepted
- 1Mudanjiang Medical University, Mudanjiang, China
- 2Mudanjiang Medical University Affiliated Hongqi Hospital, Mudanjiang, China
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The research examines the impact of endoplasmic reticulum stress (ERS) on skeletal muscle atrophy in type 2 diabetic mellitus (T2DM) mice. T2DM mouse models were established to compare skeletal muscle characteristics, ERS marker expression, and apoptosis between experimental and agematched control groups. The results demonstrated significant skeletal muscle atrophy in T2DM mouse models, accompanied by upregulated expression of ERS-related proteins, increased apoptotic proteins, decreased p-Akt expression, elevated levels of the muscle atrophy marker F-box protein 1 (Atrogin1), enhanced proteolysis, and aggravated skeletal muscle atrophy. These findings establish new mechanistic insights into diabetic muscle atrophy pathophysiology and provide both theoretical and experimental foundations for developing ERS-targeted therapeutic interventions.
Keywords: Type 2 diabetic mellitus, Endoplasmic Reticulum Stress, Apoptosis, skeletal muscle atrophy, proteostasis
Received: 08 Apr 2025; Accepted: 04 Jun 2025.
Copyright: © 2025 Yang, Wang, Xu, Jia and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xinqi Jia, Mudanjiang Medical University Affiliated Hongqi Hospital, Mudanjiang, China
Fangping Lu, Mudanjiang Medical University, Mudanjiang, China
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