ORIGINAL RESEARCH article
Front. Physiol.
Sec. Integrative Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1609482
Establishment of a Stellate Ganglion Regulation Model in Mice Using Infrared Polarized Light Irradiation
Provisionally accepted
- Plastic Surgery Hospital (PSH), Chinese Academy of Medical Sciences andPeking Union Medical College, Beijing, China
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Objective: To explore the feasibility of establishing a mouse stellate ganglion (SG) regulation model through infrared polarized light (IPL) irradiation of the SG, and preliminarily evaluate its effects on SG function and related physiological indicators. surgery, and IPL groups, with 8 mice in each group. A ZZIR-ID therapeutic device was used to directly irradiate bilateral SG regions of IPL group mice, with wavelength 980 nm, power density 1000 mW/cm2,10 minutes per session (5 minutes per side), every other day for 6 times. The control group received no treatment, while the Results: Compared with the control and Sham surgery groups, the incidence of Horner's syndrome in the IPL group increased significantly (P<0.05), manifesting as bilateral ptosis and enophthalmos, lasting about 2 hours. Immediately after treatment, eye temperature in the IPL group increased significantly compared to pre-treatment (P<0.05). Heart rate in the IPL group decreased significantly 30 minutes post-treatment compared to pre-treatment (P<0.01), lasting 1-2 hours. There was no statistically significant difference in weight changes between groups (P>0.05). In all treated mice, the characteristic signs of Horner’s syndrome developed within minutes of starting IPL exposure, reached their peak intensity between 1.5 and 2.5 hours, and resolved completely within 3–4 hours of the 10‑minute irradiation session. Conclusion: IPL irradiation of SG can effectively induce Horner’s syndrome in mice, elevate eye temperature, and reduce heart rate. These findings suggest IPL as a potential method for modulating SG activity in preclinical models.
Keywords: Stellate Ganglion, infrared polarized light, Horner's syndrome, Heart Rate, animal model
Received: 16 Apr 2025; Accepted: 06 Aug 2025.
Copyright: © 2025 Zhao, Zhang, Liu, Zhou, Juan, Wang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dong Yang, Plastic Surgery Hospital (PSH), Chinese Academy of Medical Sciences andPeking Union Medical College, Beijing, 100730, China
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