ORIGINAL RESEARCH article
Front. Physiol.
Sec. Respiratory Physiology and Pathophysiology
Surgical Hyoid Bone Repositioning Effects on Mandibular Advancement and Upper Airway Collapsibility: An Anesthetized Rabbit Model Study
Provisionally accepted
- 1Sleep and Upper Airway Research Group (SUARG), American University of Beirut, Beirut, Lebanon
- 2Department of Dentofacial Medicine, American University of Beirut Medical Centre, Beirut, Lebanon
- 3School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States
- 4Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States
- 5Biomedical Engineering Program, Maroun Semaan Faculty of Engineering and Architecture (MSFEA), American University of Beirut, Beirut, Lebanon
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Background: Mandibular advancement serves as a treatment option for obstructive sleep apnea (OSA), but its effectiveness differs among patients. The position of the hyoid bone is crucial for maintaining upper airway patency and may influence mandibular advancement outcomes. This study aimed to assess the impact of surgical hyoid re-positioning on mandibular advancement-induced changes in upper airway collapsibility in an animal model. Methods: Twelve anesthetized male New Zealand White rabbits underwent mandibular advancement (0-4mm), combined with hyoid repositioning in various directions (anterior, cranial, caudal, anterior-cranial, anterior-caudal) and increments (0-4mm). Upper airway collapsibility was quantified as the negative pressure required to close the airway (Pclose) at various mandibular and hyoid positions. Results: Increasing mandibular advancement alone led to a progressive reduction in Pclose, indicating a decrease in upper airway collapsibility. Similarly, anterior hyoid repositioning alone resulted in incremental reductions in Pclose, with similar outcomes observed for anterior-cranial and anterior-caudal directions. When mandibular advancement was combined with anterior-based hyoid repositioning directions, a further decrease in Pclose was observed compared to when either intervention was applied alone. Cranial and caudal hyoid repositioning had no direct effect on Pclose or on mandibular advancement outcomes. Conclusions: In summary, decreases in upper airway collapsibility induced by mandibular advancement are dependent on both hyoid repositioning direction and increment. The findings suggest that combining mandibular advancement with anterior-based hyoid repositioning may enhance the effectiveness of mandibular advancement in treating OSA.
Keywords: obstructive sleep apnea, osa, Upper airway surgery, Oral appliance, mandibularadvancement splint, Closing pressure, Pharynx, hyomandibular suspension
Received: 25 Apr 2025; Accepted: 27 Oct 2025.
Copyright: © 2025 Tannous, Samaha, Chami, Ghafari and Amatoury. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jason Amatoury, jason.amatoury@aub.edu.lb
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