MINI REVIEW article
Front. Physiol.
Sec. Renal Physiology and Pathophysiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1624077
This article is part of the Research TopicMolecular Pathways involved in the Pathogenesis of Diabetic Kidney DiseaseView all articles
The Role of Natural Products in Improving Lipid Metabolism Disorder-Induced Mitochondrial Dysfunction of Diabetic Kidney Disease
Provisionally accepted
- 1Ningbo Municipal Hospital of Traditional Chinese Medicine, Ningbo, China
- 2Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
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Diabetic Kidney Disease (DKD) is one of the most common microvascular complications of diabetes mellitus and an important cause of end-stage renal disease, with a complex pathogenesis and a lack of effective treatment. Lipid metabolism disorders play a key role in the progression of DKD, mainly by inducing mitochondrial dysfunction which in turn promotes renal injury. In recent years, natural products have shown great promise in improving lipid metabolism and mitochondrial homeostasis by virtue of their advantages of multi-targeting and low toxicity. In this article, we review the mechanism of mitochondrial dysfunction induced by lipid metabolism disorders in DKD, and the intervention strategies of natural products.
Keywords: Diabetic kidney disease, Lipid Metabolism, Mitochondria, monomers, Chinese medicine
Received: 07 May 2025; Accepted: 02 Jun 2025.
Copyright: © 2025 Deng, Zhu, Xing, Gao, Duan, Liu, Zhong and Cai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Peng Liu, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
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