The Dual Burden of Obesity: Decoding Metabolism and Female Reproductive Endocrinology

Yan Chen^1,2,3Rongyu Wang^1,3,4Nannan Zhang^3,5*Liangzhi Xu^1,2,3*

• ¹Reproductive Endocrinology and Regulation Laboratory，West China Second University Hospital, Sichuan University, Chengdu, China
• ²Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China
• ³Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China
• ⁴Department of Traditional Chinese Medicine, West China Second University Hospital, Sichuan University, Chengdu, China
• ⁵National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, China

The global prevalence of obesity continues to rise, posing a threat to health, especially among women, where obesity can lead to reproductive endocrine disorders. Adipose tissue interacts with endocrine hormones, including insulin, leptin, and sex hormones, resulting in functional abnormalities of the female hypothalamic-pituitary-ovarian axis through various central and peripheral mechanisms. At the same time, systemic inflammation, intestinal microbiota, and metabolites are also implicated in these processes, further linking metabolic imbalance to reproductive endocrine dysfunction. Therefore, targeting these co-regulatory mechanisms is expected to improve metabolic disorders and reproductive endocrine dysfunction in obese women. Strategies for treating obesity include dietary and behavioral interventions, medication, surgical treatment, and traditional and alternative medical therapies, showing benefits for improving reproductive endocrine dysfunction. This review calls on clinicians to This is a provisional file, not the final typeset article pay attention to the impact of obesity on reproductive health in women and proposes possible intervention measures.