ORIGINAL RESEARCH article
Front. Physiol.
Sec. Gastrointestinal Sciences
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1643597
Crohn's Disease in Coastal China: Epidemiological Profile and Determinants of Diagnostic Delay in the Yancheng Cohort
Provisionally accepted
- 1Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Yancheng, China
- 2Yancheng No 1 People's Hospital, Yancheng, China
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Background and Aims: Crohn's disease (CD) exhibits escalating incidence in China, particularly in coastal regions undergoing rapid industrialization. We aim to investigate the epidemiological characteristics of CD and identify factors influencing diagnostic delay in the Yancheng region of China.A cross-sectional analysis was conducted on CD patients from two tertiary medical centers (Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine and Yancheng No.1 People's Hospital) between October 2021 and October 2024. Crude prevalence, incidence rates, and predictors of diagnostic delay were analyzed using logistic regression models.Results: Among 200 enrolled CD patients (male-to-female ratio: 2.07:1), the crude prevalence and incidence rates were 17.48/100,000 and 2.3/100,000, respectively. Diagnostic delay occurred in 48% (96/200) of cases, with a median delay duration of 23 months (IQR: 12-48; maximum: 300 months). Multivariate analysis identified advanced age at diagnosis as an independent risk factor for delay (OR=1.035, 95% CI: 1.010-1.060, P=0.005), while abdominal pain served as a protective factor (OR=2.088, 95% CI: 1.136-3.838, P=0.018). Diagnostic delay duration correlated positively with age at diagnosis (r=0.302, P=0.003) and frequency of refrigerated food consumption (r=0.219, P=0.032). No significant associations were observed between delay duration and complications such as intestinal obstruction, perforation, or surgical intervention (P＞0.05).The Yancheng region exhibits higher CD prevalence and incidence rates compared to national averages, with pronounced diagnostic delays. These findings highlight the need for targeted interventions to improve early diagnosis and mitigate healthcare burdens.
Keywords: Crohn's disease, Epidemiology, diagnostic delay, China, Yancheng
Received: 11 Jun 2025; Accepted: 04 Aug 2025.
Copyright: © 2025 Jin, Zhang, Zhou, Hao, Wang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Su Xu, Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Yancheng, China
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