SYSTEMATIC REVIEW article
Front. Physiol.
Sec. Exercise Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1646833
This article is part of the Research TopicStrategies for Combatting Age-Related Decline through Targeted Exercise ProgramsView all 5 articles
The effects of Vivifrail-based multicomponent training on physical and cognitive function in frail older adults: a systematic review and meta-analysis
Provisionally accepted
- 1Shandong University, Jinan, China
- 2Guangdong Vocational Academy of Art, guangzhou, China
- 3Guangzhou Academy of Fine Arts, Guangzhou, China
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Objectives: Vivifrail is a personalized, multicomponent exercise program that has emerged in recent years. This systematic review and meta-analysis aimed to assess the effects of Vivifrail-based multicomponent training on physical and cognitive function in frail older adults.Methods: A systematic search was conducted following the PRISMA guidelines, using the following databases: PubMed, Web of Science, The Cochrane Library, EBSCOhost, and Embase, covering studies up to May 26, 2025. The included studies were assessed for quality using the Effective Public Health Practice Project quality assessment tool. Data were analyzed using random-effects metaanalysis.Results: Twelve studies, including 1,026 participants, were included in the meta-analysis. Vivifrailbased multicomponent training showed significant beneficial effects on the Short Physical Performance Battery (SPPB) (SMD = 0.90; 95% CI: 0.50, 1.30; P < 0.001; I 2 = 88.1%), grip strength (SMD = 0.62; 95% CI: 0.37, 0.87; P < 0.001; I 2 = 68.9%), and cognitive function (SMD = 0.60; 95% CI: 0.34, 0.86; P < 0.001; I 2 = 56.9%) compared to the usual care group. No significant effects were observed on the Barthel Index of activities of daily living (ADL) (SMD = 0.87; 95% CI: -0.12, 1.85; P = 0.083; I 2 = 95.7%). Furthermore, no significant risk of publication bias was detected for any outcomes.Current evidence suggests that Vivifrail-based multicomponent training significantly improves physical and cognitive function. However, the results should be interpreted with caution due to high heterogeneity in the meta-analysis.
Keywords: Vivifrail, Multicomponent training, physical function, Cognitive Function, Frailty
Received: 14 Jun 2025; Accepted: 18 Jul 2025.
Copyright: © 2025 Chen, Liu, Zhao, Yao and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yanyu Lu, Guangzhou Academy of Fine Arts, Guangzhou, China
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