REVIEW article
Front. Physiol.
Sec. Cell Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1647865
Advancements in Macrophage Research for Cardiovascular Disease
Provisionally accepted
- 1The First Affiliated Hospital of China Medical University, Shenyang, China
- 2Shengjing Hospital of China Medical University, Shenyang, China
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Cardiovascular disease is a major cause of human morbidity and mortality. With the rising prevalence of cardiovascular diseases and their increasing economic impact on individuals and society, a deeper understanding of their pathogenesis is essential.Macrophages play the crucial role in this regulatory network as key cell types in the innate immune system. This review provides an overview of the subpopulations, heterogeneity, and ontogenetic diversity of macrophages. It emphasizes how various cellular metabolic processes influence the biological functions of macrophages.Additionally, it explores the mechanisms through which macrophages function in different cardiovascular diseases (e.g., atherosclerosis, hypertension, or myocardial infarction) and examines their potential therapeutic applications. The review also addresses the current limitations and future directions for research and therapeutic strategies involving cardiac macrophages in cardiovascular diseases.
Keywords: Atherosclerosis, cardiovascular disease, cell metabolism, Hypertension, macrophage, mechanism of action, Myocardial Infarction
Received: 16 Jun 2025; Accepted: 25 Jul 2025.
Copyright: © 2025 Cao, Sun, Zhang, Zou, Shi, Li and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hongkun Jiang, The First Affiliated Hospital of China Medical University, Shenyang, China
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