ORIGINAL RESEARCH article
Front. Physiol.
Sec. Exercise Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1649300
This article is part of the Research TopicStrategies for Combatting Age-Related Decline through Targeted Exercise ProgramsView all 12 articles
The Effect of Resistance Training on Physical Function Is Associated with Changes in Serum Albumin Redox States in Middle-aged and Older Japanese Adults: A Quasi-experimental Study
Provisionally accepted
- 1Morinaga Milk Industry Co Ltd., Tokyo, Japan
- 2Juntendo Daigaku Sports Kenko Kagakubu Daigakuin Sports Kenko Kagaku Kenkyuka, Inzai, Japan
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Resistance training is important for improving physical function in middle-aged and older adults. The fraction of mercaptoalbumin in total serum albumin, represented as f(HMA), is an indicator of physical function and protein nutritional status in humans. However, it is unclear whether the effects of resistance training on physical function are associated with changes in f(HMA). This study was aimed at examining the relationship between f(HMA) and the effects of resistance training in healthy middle-aged and older Japanese adults. Methods: The study included 43 healthy community dwelling middle-aged and elderly individuals (10 males and 33 females, aged 67.3 ± 8.0 years). They were engaged in a low-load, body-weight-based resistance training program using an elastic band twice a week for 12 weeks under supervision. Anthropometric data, 6-meter gait speed, blood biochemistry, and dietary macronutrient intake were collected before and after the training intervention. The relationships between serum nutritional parameters and gait speed or their rate of change were examined using multivariate linear regression analysis. Results: Before intervention, f(HMA) showed a significant positive correlation with the usual (β = 0.326, P = 0.045) and maximum (β = 0.331, P = 0.036) gait speeds. The changing rate of maximal gait speed showed a significant positive correlation with the rate of increase in f(HMA) (β = 0.456, P = 0.004). Conclusion: Serum f(HMA) increased with improvements in physical function through resistance training in middle-aged and older adults.
Keywords: albumin, Exercise, Frailty, protein, Sarcopenia
Received: 18 Jun 2025; Accepted: 28 Aug 2025.
Copyright: © 2025 Shibasaki, Nakamura, Kurosaka, Sawada, Miyaji and Machida. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Takuya Shibasaki, Morinaga Milk Industry Co Ltd., Tokyo, Japan
Shuichi Machida, Juntendo Daigaku Sports Kenko Kagakubu Daigakuin Sports Kenko Kagaku Kenkyuka, Inzai, Japan
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.