REVIEW article
Front. Physiol.
Sec. Integrative Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1651151
Gut to Brain: Essential Micronutrient and Trace Element Manganese Transport, Function and Toxicity
Provisionally accepted
- Cornell University, Ithaca, United States
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This review provides a comprehensive analysis of manganese (Mn) metabolism and its regulatory roles across multiple biological levels. By examining Mn homeostasis mechanisms, including Mn absorption, excretion, distribution, and transport across the intestines, liver, and brain, this work highlights the integrative nature of Mn physiology. Additionally, it explores routes of Mn overexposure and the consequences of Mn dysregulation on various organ systems, with a focus on neurotoxicity, as well as the genetic and environmental factors that contribute to Mn homeostasis. This review synthesizes insights into metal transporters to advance our understanding of their roles in maintaining systemic and brain Mn homeostasis under healthy conditions and their contribution to Mn dysregulation in disease states, particularly neurological disorders. By focusing on Mn transport and regulation across multiple physiological systems and its impact on health and disease, we aim to bridge the gap between molecular-level processes and whole-body physiology.slc39a14
Keywords: ZIP14, Slc39a14, Zip8, SLC39A8, SLC30A10, ZnT10, transport, parkinsonism
Received: 20 Jun 2025; Accepted: 23 Oct 2025.
Copyright: © 2025 Zou, Yerramilli and Aydemir. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tolunay B Aydemir, tb536@cornell.edu
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