PERSPECTIVE article
Front. Physiol.
Sec. Vascular Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1651249
This article is part of the Research TopicUnraveling the Influence of Perivascular Adipose Tissue on Vascular HealthView all 6 articles
Clinical Correlates of Perivascular Adipose Tissue in Coronary Artery Disease and Obesity
Provisionally accepted
- 1John W. Deming Department of Medicine, Section of Cardiology, Tulane University School of Medicine, New Orleans, United States
- 2John W. Deming Department of Medicine, Section of Cardiology, Tulane University, New Orleans, United States
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The adipose tissue around the arterial and venous vasculature and microvasculature affects vascular reactivity and pathology particularly when perivascular adipose tissue accumulates in overweight and obese states. In the absence of convenient techniques to measure local blood flow and adipose tissue volume, perivascular adipose tissuerelated alterations are scantly considered in clinical settings. Further, perivascular adipose tissue accumulation frequently coexists with obesity and obesity on its own leads to functional and structural vascular alterations.The proximity of epicardial adipose tissue to the coronary arteries provides a unique opportunity to study the effects of perivascular adipose tissue on vascular pathology and reactivity. As coronary atherosclerotic plaque inflammation contributes to the inflammatory response of surrounding adipose tissue, pericoronary adipose tissue attenuation may predict the risk of acute coronary events. Lastly, perivascular adipose tissue accumulation may mediate obesity-associated regional subclinical left ventricular dysfunction in the absence of coronary artery disease.
Keywords: epicardial adipose tissue, visceral abdominal fat, Coronary arter disease, Heart Failure, perivascular adipose tissue
Received: 21 Jun 2025; Accepted: 07 Aug 2025.
Copyright: © 2025 Upadhaya, Pandey, Wiley and Le Jemtel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Thierry H Le Jemtel, John W. Deming Department of Medicine, Section of Cardiology, Tulane University School of Medicine, New Orleans, United States
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