REVIEW article
Front. Physiol.
Sec. Biophysics
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1651258
Piezo in the eye: expression, distribution and roles in ocular diseases
Provisionally accepted
- 1Operating Room, The Affiliated Hospital of Qingdao University, Qingdao, China
- 2The Affiliated Hospital of Qingdao University, Qingdao, China
- 3Ocean University of China, Qingdao, China
- 4Jining Medical University, Jining, China
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Piezo channels are currently known to be the most sensitive molecular mechanoreceptors. Piezo can respond to membrane tension, sag, shear force, tensile and other mechanical stimuli, produces fast inactivation, small conductance, and low threshold current. In eukaryotic cells, Piezo has two family members: Piezo1 and Piezo2. Functionally, Piezo1 detects whole-membrane tension changes, including swelling and compression. Piezo2 is more likely to sense specific mechanical stimuli, including touch and airway stretching. In the ocular system, Piezo1 and Piezo2 are expressed across various cells and tissues. This article provides a comprehensive review of the expression, distribution, and function of Piezo channels in ocular tissues, offering novel insights for the treatment of eye diseases.
Keywords: Piezo channels, Glaucoma, IOP, RGC, ONH
Received: 21 Jun 2025; Accepted: 25 Jul 2025.
Copyright: © 2025 Zhu, Ren, He, Liu and Hou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fei Hou, Operating Room, The Affiliated Hospital of Qingdao University, Qingdao, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.