REVIEW article
Front. Physiol.
Sec. Integrative Physiology
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1651589
This article is part of the Research TopicExploring the Physiological and Molecular Benefits of Physical Exercise in Cardiovascular DiseasesView all 3 articles
The New Perspective of Cardiac Exercise Rehabilitation: Based on Integrative Physiology
Provisionally accepted
- 1Department of Physical Education, Xiamen University of Technology, Xiamen, China
- 2Changzhi Medical College, Changzhi, China
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Cardiovascular diseases (CVDs) are the world's leading cause of death, but there's a gap between scientific research and real-world treatment. Exercise is a safe and effective way to prevent and manage CVDs, yet putting it into practice faces many challenges. This review shows how exercise protects the heart by improving metabolism, reducing inflammation and cell damage, and strengthening connections between heart cells and blood vessels. Exercise establishes a multi-organ defense network involving remote organs including the brain, skeletal muscle, adipose tissue, liver, and kidneys. To bridge the gap between research and clinical use, future efforts should focus on developing exercise-like drugs, personalized workout plans, and remote rehabilitation programs.
Keywords: Cardiac Rehabilitation, Integrative Physiology, Exercise rehabilitation, cardiovascular, aerobic exercise
Received: 22 Jun 2025; Accepted: 12 Aug 2025.
Copyright: © 2025 You, Xie, Tong and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shaocong Zhao, Department of Physical Education, Xiamen University of Technology, Xiamen, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.