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ORIGINAL RESEARCH article

Front. Physiol.

Sec. Exercise Physiology

Volume 16 - 2025 | doi: 10.3389/fphys.2025.1653032

Resistance Exercise Promotes Functional Recovery from Peripheral Nerve Injury

Provisionally accepted
  • Kuwait University, Kuwait City, Kuwait

The final, formatted version of the article will be published soon.

Studies on the effect of exercise before peripheral nerve injuries are scarce, with even less attention given to the effects of resistance exercise. In this study, rats were first trained for 10 weeks using a novel resistance exercise system developed in our laboratory, and then they were subjected to either a mild compression or a moderate crush injury of their sciatic nerve. Functional tests, including toe spread reflex, foot positioning, extensor postural thrust, and CatWalk, were carried out at pre-and on selected days post-injury. Animals were sacrificed, and sciatic nerves were collected on the 5th day and the 14th day after the compression and crush-injured rats, respectively. Myelin proteins were analyzed using Western blot, and the morphology and morphometric parameters of the injury site were assessed using transmission electron microscopy (TEM). Nerve compression-injured rats showed no significant difference between resistance-exercised and control rats on either their functional performance, levels of myelin proteins, morphology, or morphometric measurements. On the other hand, in nerve crush injury, the resistance exercise rats performed better in toe spread and extensor postural thrust scores when compared to the injured controls. The TEM revealed that distal segments of crush-injured nerves of the resistance-exercised rats had better morphology compared to those of the crush-injured controls. However, compared to the control, the resistance exercise crush injury showed significant differences in the level of myelin proteins and the morphometric measurements.

Keywords: strength training, axonal myelination, Catwalk test, toe spread reflex, Transmission electron microscopy

Received: 24 Jun 2025; Accepted: 06 Oct 2025.

Copyright: © 2025 Al-sarraf, AlMallah and Mouihate. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Hameed Al-sarraf, hameed.alsarraf@ku.edu.kw

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