Your new experience awaits. Try the new design now and help us make it even better

ORIGINAL RESEARCH article

Front. Physiol.

Sec. Computational Physiology and Medicine

Volume 16 - 2025 | doi: 10.3389/fphys.2025.1662104

This article is part of the Research TopicMedical Knowledge-Assisted Machine Learning Technologies in Individualized Medicine Volume IIView all 20 articles

Structure-Guided Deep Learning for Back Acupoint Localization via Bone-Measuring Constraints

Provisionally accepted
Yulong  WangYulong Wang1Tian  LanTian Lan2Wenjian  DouWenjian Dou3Zhi  ChenZhi Chen4Song  ZhangSong Zhang3Gong  ChenGong Chen1,3*
  • 1School of Artificial Intelligence and Information Technology, Nanjing University of Chinese Medicine, Nanjing, China
  • 2School of Computer Science, Inner Mongolia University, China
  • 3Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China
  • 4Institute of Chinese Medicine Literature, Nanjing University of Chinese Medicine, Nanjing, China

The final, formatted version of the article will be published soon.

Accurate acupoint localization is crucial for the effectiveness of acupuncture and related Traditional Chinese Medicine (TCM) therapies. This study introduces a novel automated framework for recognizing back acupoints, uniquely integrating the traditional TCM bone-measuring principle with advanced deep learning for medical image analysis. The method employs an HRFormer backbone network combined with a Structure-Guided Keypoint Estimation Module (SG-KEM) and a structureconstrained loss function, ensuring anatomically consistent predictions within a standardized spatial coordinate system to improve accuracy across diverse body types.Trained and evaluated on a dataset of 430 high-resolution back images with 19 annotated acupoints, the framework achieved a normalized mean error (NME) of 0.6%, a failure rate (FR@1cm) of 1.2%, an area under the curve (AUC) of 0.97, and a precision of 93.8%, while operating in real-time at 18 frames per second. Component analysis confirmed significant contributions: the SG-KEM module reduced the mean error by 33.3%, and the structure-constrained loss further decreased it to 0.6%. Moreover, ablation studies under challenging conditions validated the model's robustness. On the obese subset, the NME decreased from 1.5% to 0.8%, FR@1cm dropped from 4.0% to 1.3%, and precision improved from 83.8% to 93.4%. Under illumination variation, the model achieved an NME of 0.9%, outperforming both HRFormer (1.3%) and HRFormer+SG-KEM (1.1%), with corresponding increases in AUC and precision. These findings demonstrate strong generalization across diverse clinical scenarios.Collectively, these results establish a clinically viable and computationally efficient solution for intelligent acupoint localization, supporting AI-assisted diagnosis and personalized treatment strategies within modern TCM healthcare systems.

Keywords: Acupoint localization, HRFormer, Anatomical landmark detection, Bone-Measuring Method, medical imaging, artificial intelligence

Received: 08 Jul 2025; Accepted: 13 Aug 2025.

Copyright: © 2025 Wang, Lan, Dou, Chen, Zhang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Gong Chen, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.