SYSTEMATIC REVIEW article
Front. Physiol.
Sec. Mitochondrial Research
Volume 16 - 2025 | doi: 10.3389/fphys.2025.1695681
This article is part of the Research TopicMechanisms and Novel Therapeutic Targets and Approaches for Mitochondrial Dysfunction in Neurological and Cardiovascular DiseasesView all 7 articles
Mitochondrial quality control in neurodegenerative diseases: From molecular mechanisms to natural product therapies
Provisionally accepted
- 1Shandong University of Traditional Chinese Medicine, Jinan, China
- 2Beijing University of Chinese Medicine, Beijing, China
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Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, etc., are a group of complex and heterogeneous disorders characterized by progressive synaptic loss and pathological protein alterations. Mitochondria are the main source of energy produced by neurons and support the high energy consumption of the nervous system. Mitochondrial quality control, involving processes like mitophagy and mitochondrial biogenesis, is crucial for mitochondrial homeostasis, and mitochondrial dysfunction is closely related to neurodegenerative diseases pathogenesis, making targeting mitochondrial quality control a potential therapeutic strategy. This review summarizes the functional characteristics and biological events of mitochondrial quality control systems in neurodegenerative diseases pathogenesis, and comprehensively analyzes the pharmacological mechanisms by which natural products regulate mitochondrial quality control to improve neurodegenerative diseases, aiming to provide a scientific basis for further research and new clinical drug development.
Keywords: Neurodegenerative Diseases, Mitochondrial quality control, Molecular mechanisms, Natural Products, Toxicology and adverse effects
Received: 30 Aug 2025; Accepted: 30 Sep 2025.
Copyright: © 2025 Chen, Wang, Wang, Liu, Chen, Mao, Li, Liu and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qi Liu, liuqixiaobai@126.com
Xue Zhou, sdzyyzx@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.