SYSTEMATIC REVIEW article
Front. Physiol.
Sec. Renal Physiology and Pathophysiology
Current Perspectives and Trends on the Role of Mitochondria in Renal Ischemia-Reperfusion Injury from 2005 to 2024: A Bibliometric Analysis and Literature Review
Provisionally accepted
- Department of Urology, Lanzhou University Second Hospital, Lanzhou, China
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Background: Renal ischemia-reperfusion injury (RIRI) represents a leading cause of acute kidney injury (AKI). Mitochondria, serving as the central organelles for cellular energy metabolism and signal transduction, play a pivotal role in the pathogenesis of RIRI. Methods: Utilizing the three major academic databases—Web of Science Core Collection (WoSCC), PubMed, and Scopus, this study conducted a comprehensive bibliometric analysis and visualization to explore research trends and key thematic areas related to mitochondrial involvement in renal ischemia-reperfusion injury from 2005 to 2024. Results: Bibliometric analysis reveals a sustained increase in research output concerning mitochondrial roles in RIRI over the past two decades. China and the United States have emerged as the most active contributors in this field. The U.S. Department of Veterans Affairs leads in terms of total publications, while Dong Zheng from the Second Xiangya Hospital of Central South University has contributed the highest number of publications by an individual author. Kidney International and the Journal of the American Society of Nephrology are the most frequently cited journals. This study systematically identified key research themes, including the mechanisms of mitochondrial dysfunction in RIRI, mitochondrial quality control mechanisms, and potential therapeutic strategies targeting mitochondria. This is a provisional file, not the final typeset article Conclusion: Through bibliometric analysis, this study elucidates the knowledge structure and developmental trends in mitochondrial research related to RIRI. Over the past 20 years, mitochondrial dysfunction, mitochondrial quality control, and mitochondria-targeted therapeutic approaches have consistently constituted major research hotspots in this domain.
Keywords: renal ischemia-reperfusion injury, Mitochondrial quality control, mitochondrialmetabolic reprogramming, Bibliometrics, targeted therapy
Received: 03 Oct 2025; Accepted: 24 Nov 2025.
Copyright: © 2025 Yan, Zhang, Li, Li, Man and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Li Yang
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