ORIGINAL RESEARCH article
Front. Physiol.
Sec. Autonomic Neuroscience
This article is part of the Research TopicAutonomic Nervous System-targeting Therapies for Cardiovascular DiseasesView all 5 articles
Sympathetic vasomotion as an early marker of hemorrhage
Provisionally accepted
- University of Nebraska Medical Center, Omaha, United States
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Each year, over 1.8 million people die from hemorrhagic shock, and, since the median time from onset to death is only two hours, early recognition is the cornerstone of management. The sympathetic nervous system is the fastest physiological hemodynamic compensatory mechanism, and we have developed a novel measure of sympathetic vascular control called sympathetic vasomotion which could serve as an early marker of hemorrhage. We performed unilateral renal denervation on six rabbits and instrumented these rabbits with bilateral renal flow probes and arterial pressure telemeters to allow for measurement of sympathetic vasomotion in paired vascular beds that differed only by sympathetic innervation. After a two-week recovery period, conscious rabbits then underwent controlled blood withdrawal via an auricular arterial catheter to simulate hemorrhage. Vasomotion differences between innervated and denervated kidneys in admittance gain, phase shift, and coherence increased significantly prior to increases in heart rate or decreases in blood pressure. These data suggest that sympathetic vasomotion could be a useful physiologically based biomarker for the early detection of hemorrhage. Further studies are needed to evaluate the utility of monitoring the sympathetic nervous system in clinical settings.
Keywords: Blood Pressure, Hemorrhage, Renal Circulation, signal processing, digital, Sympathetic Nervous System
Received: 24 Sep 2025; Accepted: 28 Oct 2025.
Copyright: © 2025 Pellegrino, Schiller, Pipinos, Zucker and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Peter Ricci Pellegrino, peter.ricci.pellegrino@gmail.com
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