About this Research Topic
The intricate network of blood vessels in the human body plays a fundamental role in maintaining tissue homeostasis and organ function. Endothelial cells lining these vessels regulate vascular tone, permeability, and angiogenesis, and are crucial for physiological processes. However, disturbances in homeostasis lead to endothelial dysfunction, a hallmark of various pathological conditions. Recent evidence highlights the significant impact of phenotypic transitioning profiles, such as endothelial-to-mesenchymal transition (EndMT), on tissue homeostasis. These transitions involve endothelial cells and other vascular cells acquiring new characteristics, leading to dynamic changes in their function and behavior. While these transitions are essential in physiological contexts like wound healing, they can drive pathological changes when dysregulated. Dysfunctional endothelial cells can undergo transitions that contribute to vascular pathology and further exacerbate endothelial dysfunction, leading to a progressive deterioration of vascular health and contributing to cardiovascular diseases such as atherosclerosis and hypertension. Additionally, it is well-known that vascular smooth muscle, fibroblasts, adipocytes, and inflammatory cells also show phenotypic transitioning profiles that impact the overall tissue homeostasis.
The overarching goal of this Research Topic is to elucidate the intricate interplay between endothelial dysfunction and vascular damage, with a specific focus on the impact of phenotypic transitioning profiles. By synthesizing current research findings and insights, we seek to highlight how phenotypic transitions of endothelial cells and other vascular cells regulate tissue remodeling, function, and regeneration in disease states. Furthermore, this collection aims to explore signaling pathways involved in immune cell modulation, platelet aggregation, and thrombus formation, identifying novel therapeutic targets and evaluating interventions to mitigate the feedback loop between endothelial dysfunction phenotypic transitions and prevent adverse vascular damage. Our hope is to contribute to a more comprehensive understanding of the underlying mechanisms driving vascular remodeling and endothelial dysfunction in various cardiovascular diseases, such as atherosclerosis, hypertension, diabetes, stroke, aneurysm, myocardial infarction, heart failure, and many more.
We welcome submissions encompassing basic, translational, and clinical research focused on elucidating molecular and cellular mechanisms, and the physiological consequences of endothelial dysfunction and vascular damage, focusing on remodeling and phenotypic transitioning of vascular cells. Studies exploring novel diagnostic biomarkers and therapeutic targets, as well as new techniques to evaluate endothelial properties are desired. Moreover, the elucidation of new therapeutic targets, and interventions focusing on the reversion of pathological vascular remodeling in cardiovascular diseases, as well as the contribution of environmental factors, and genetic and epigenetic regulators of endothelial function are of interest. A list of potential topics of interest has been included below, but relevant papers on related themes are welcome.
● Mechanisms underlying endothelial dysfunction and phenotypic transitioning of vascular and immune cells in cardiovascular diseases
● Signaling pathways regulating the endothelial function in the pathological vascular remodeling
● Role of immune cells and inflammatory mediators in endothelial dysfunction and vascular remodeling in cardiovascular diseases
● Contribution of oxidative stress to endothelial dysfunction and aberrant vascular remodeling
● Genetic and epigenetic factors influencing endothelial phenotype and function in vascular remodeling
● Endothelial progenitor cells, stem cells, and vascular regeneration to prevent cardiovascular diseases
● New techniques and diagnostic biomarkers for assessing endothelial dysfunction
● Non-pharmacological and pharmacological strategies targeting endothelial dysfunction and vascular remodeling
● Influence of lifestyle factors (e.g., diet, exercise) in the reversion of vascular damage
● Influence of environmental exposures (e.g., pollution, toxins) on endothelial function and the impact on endothelial function and vessel remodeling
● Emerging technologies for studying endothelial biology and vascular remodeling
● Patient-specific and Personalized Medicine Approaches for Tailored Therapeutics in Cardiovascular Diseases
● Exploring the Role of Microbiota in Cardiovascular Health and Endothelial Dysfunction
● Utilizing Advanced Imaging Techniques for Enhanced Visualization and Analysis of Vascular Structures
● Leveraging Data Science and Machine Learning to Predict and Analyze Trends in Cardiovascular Diseases and Endothelial Dysfunction
● Investigating the Impact of Mechanical Forces on Endothelial Function and Vascular Remodeling
The overarching goal of this Research Topic is to elucidate the intricate interplay between endothelial dysfunction and vascular damage, with a specific focus on the impact of phenotypic transitioning profiles. By synthesizing current research findings and insights, we seek to highlight how phenotypic transitions of endothelial cells and other vascular cells regulate tissue remodeling, function, and regeneration in disease states. Furthermore, this collection aims to explore signaling pathways involved in immune cell modulation, platelet aggregation, and thrombus formation, identifying novel therapeutic targets and evaluating interventions to mitigate the feedback loop between endothelial dysfunction phenotypic transitions and prevent adverse vascular damage. Our hope is to contribute to a more comprehensive understanding of the underlying mechanisms driving vascular remodeling and endothelial dysfunction in various cardiovascular diseases, such as atherosclerosis, hypertension, diabetes, stroke, aneurysm, myocardial infarction, heart failure, and many more.
We welcome submissions encompassing basic, translational, and clinical research focused on elucidating molecular and cellular mechanisms, and the physiological consequences of endothelial dysfunction and vascular damage, focusing on remodeling and phenotypic transitioning of vascular cells. Studies exploring novel diagnostic biomarkers and therapeutic targets, as well as new techniques to evaluate endothelial properties are desired. Moreover, the elucidation of new therapeutic targets, and interventions focusing on the reversion of pathological vascular remodeling in cardiovascular diseases, as well as the contribution of environmental factors, and genetic and epigenetic regulators of endothelial function are of interest. A list of potential topics of interest has been included below, but relevant papers on related themes are welcome.
● Mechanisms underlying endothelial dysfunction and phenotypic transitioning of vascular and immune cells in cardiovascular diseases
● Signaling pathways regulating the endothelial function in the pathological vascular remodeling
● Role of immune cells and inflammatory mediators in endothelial dysfunction and vascular remodeling in cardiovascular diseases
● Contribution of oxidative stress to endothelial dysfunction and aberrant vascular remodeling
● Genetic and epigenetic factors influencing endothelial phenotype and function in vascular remodeling
● Endothelial progenitor cells, stem cells, and vascular regeneration to prevent cardiovascular diseases
● New techniques and diagnostic biomarkers for assessing endothelial dysfunction
● Non-pharmacological and pharmacological strategies targeting endothelial dysfunction and vascular remodeling
● Influence of lifestyle factors (e.g., diet, exercise) in the reversion of vascular damage
● Influence of environmental exposures (e.g., pollution, toxins) on endothelial function and the impact on endothelial function and vessel remodeling
● Emerging technologies for studying endothelial biology and vascular remodeling
● Patient-specific and Personalized Medicine Approaches for Tailored Therapeutics in Cardiovascular Diseases
● Exploring the Role of Microbiota in Cardiovascular Health and Endothelial Dysfunction
● Utilizing Advanced Imaging Techniques for Enhanced Visualization and Analysis of Vascular Structures
● Leveraging Data Science and Machine Learning to Predict and Analyze Trends in Cardiovascular Diseases and Endothelial Dysfunction
● Investigating the Impact of Mechanical Forces on Endothelial Function and Vascular Remodeling
Keywords: Endothelial dysfunction, Vascular damage, Vascular remodeling, Cardiovascular diseases, oxidative stress, inflammatory mediators, endothelial-to-mesenchymal transition, stem cells, tissue regeneration, genetic and epigenetic factors in cardiovascular diseases
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
