Exercise Preconditioning in Ischemia-Reperfusion Injury

Liver surgery is crucial for treating various hepatic ailments but frequently results in ischemia-reperfusion injury (IRI), a grave complication characterized by mitochondrial dysfunction during ischemia and enhanced oxidative stress upon reperfusion. This condition precipitates a severe inflammatory response, causing extensive tissue necrosis and releasing damage-associated molecular patterns (DAMPs) that potentially lead to systemic and distant organ dysfunction. Despite extensive research, effective therapeutic strategies are scarce due to the intricate interactions involving microcirculation disturbances, hypoxia, oxidative stress, and cellular demise. Current evidence suggests that employing pre-operative exercise could enhance outcomes by potentially counteracting the pathological mechanisms of liver IRI.

This Research Topic aims to dissect the complex biological mechanisms underlying liver IRI and its broad systemic implications, alongside assessing the potential of exercise pre-conditioning as a mitigative approach. The objectives focus on unraveling the metabolic, synthetic, and detoxification activities within hepatic tissues and their networks related to systemic and organ-specific dysfunction, particularly under conditions employing the Pringle maneuver during liver surgeries. Emphasis will be placed on the overarching impacts of IRI-induced inflammatory responses and DAMPs across vital organs including lungs, heart, and kidneys.

To further dissect the comprehensive landscape of liver IRI, we invite contributions in several key areas, including:
- Detailed exploration of metabolic, synthetic, and detoxification processes specific to liver IRI.
- Studies on the interplay of systemic dysfunction and organ-specific damage from IRI.
- Investigations into the inflammatory and DAMP effects on cardio-renal and pulmonary systems.
- In-depth analysis of exercise pre-conditioning as a strategy to prevent liver IRI.
- Empirical research utilizing animal models or human subjects.
- Applications of network-based modeling to understand IRI complexities.
- Comprehensive narrative and systematic reviews, including meta-analysis.
- Perspectives on implementing exercise as a pre-conditioning measure against hepatic IRI.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Ischemia-Reperfusion Injury, necrosis, apoptosis, myocardial infarction, stroke, liver transplant, damage-associated molecular pattern, network physiology, integrative physiology, liver surgery

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.