Mitochondrial Pathophysiology in Cardiomyopathy and Cardiac Senescence

Mitochondrial pathophysiology is a pivotal area of research in understanding the underlying mechanisms of cardiomyopathy and cardiac senescence. Recent advancements have shed light on the critical role of mitochondrial signals and performance in various cardiac conditions, yet a comprehensive understanding of these mechanisms remains elusive. Current research has identified key mitochondrial dysfunctions that contribute to heart diseases, but the intricate details of how these dysfunctions manifest in cardiomyopathy and cardiac senescence are not fully understood. Despite significant progress, there is a pressing need for more in-depth studies to unravel the complexities of mitochondrial involvement in these conditions. Addressing these gaps is essential for developing effective clinical therapies and improving patient outcomes in heart diseases.

This research topic aims to deepen our understanding of the complexities of mitochondrial pathophysiology in cardiomyopathy and the senescent heart, and to explore the potential of targeting mitochondria in translational physiology and clinical remedy. The primary objectives include elucidating the mitochondrial mechanisms that contribute to these cardiac conditions and investigating the potential therapeutic interventions that target mitochondrial dysfunction. By addressing these aims, the research seeks to provide a foundation for developing novel clinical therapies that can mitigate the effects of mitochondrial dysfunction in heart diseases.

To gather further insights in mitochondrial pathophysiology in cardiomyopathy and cardiac senescence, we welcome articles addressing, but not limited to, the following themes:
- Clinical characteristics of cardiac mitochondrial bioenergetics in heart disease and metabolic diseases, including diabetic vasculopathy-caused cardiovascular and peripheral arterial diseases
- Clinical and molecular aspects of the inflammation-mitochondria axis in heart disease and metabolic diseases
- Translational potential of mitochondria transplantation in heart disease
- Targeting mitochondrial epigenetics in cardiomyopathy/heart failure and senescence
- Mitochondrial regulation in cardiac regeneration
- Interaction of myocardial mitochondria with exosomes and extracellular vesicles
- Multiomics approaches and novel technologies for assessing myocardial mitochondrial responses

Contributions should focus on all levels of investigation, from subcellular and cellular studies to whole-organ analyses.

Keywords: mitochondria, cardiomyopathy, cardiac senescence, pathophysiology, bioenergetics, multiomics approaches, inflammation, extracellular vesicles, epigenetics

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.