Integrated Pancreatic Physiology: Ion Transport, Calcium Signaling, Genetics, and Functional Crosstalk in Health and Disease

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Background

The pancreas is a multifunctional organ whose exocrine and endocrine compartments work in concert to sustain metabolic and digestive homeostasis. While these systems have often been studied in isolation, mounting evidence points to their deep interdependence, regulated through a complex network of ion transport, calcium signaling, and genetic determinants. Perturbations in these pathways contribute to the development and progression of a broad range of diseases, including acute and chronic pancreatitis, cystic fibrosis, diabetes mellitus, and pancreatic cancer.

This Research Topic aims to bring together multidisciplinary research exploring:

• Ion channels and transporters in pancreatic secretion and signaling
• Calcium dynamics in acinar and islet cells
• Functional crosstalk between endocrine and exocrine compartments
• Organelle communication in stress responses (ER, mitochondria, lysosomes)
• Genetic variants and inherited disorders affecting pancreatic function
• Systems-level and personalized medicine approaches to pancreatic diseases

We welcome original research, reviews, and perspectives from the fields of physiology, molecular biology, genetics, pharmacology, and translational research. Studies utilizing cutting-edge tools—such as live-cell imaging, electrophysiology, organoids, single-cell technologies, omics approaches, and in vivo models—are especially encouraged.


Guest Editor Dr. Maša Skelin Klemen discloses that Tanin Sevnica d.d. (Sevnica, Slovenia) financially supported a research project in which she was involved. This support is unrelated to the current Research Topic, and the company has had no influence on editorial decisions or the peer review process.

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  • Hypothesis and Theory
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Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Data Report
  • Editorial
  • FAIR² Data
  • Hypothesis and Theory
  • Methods
  • Mini Review
  • Opinion
  • Original Research
  • Perspective
  • Review
  • Systematic Review
  • Technology and Code

Keywords: Pancreas, Physiology, Homeostasis, Signaling, Genetics, Endocrine-exocrine crosstalk, Disease, ion channels, Calcium signaling, Acinar cells, Islet cells, Pancreatitis, Organelle communication, genetic variant

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