Central Neuromodulation for Urogenital and Bowel Control: Innovations and Challenges in SCI Recovery

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About this Research Topic

Submission deadlines

  1. Manuscript Summary Submission Deadline 22 September 2025 | Manuscript Submission Deadline 10 January 2026

  2. This Research Topic is still accepting articles.

Background

This Research Topic intends to explore and address questions in the realm of central neuromodulation, including spinal cord epidural stimulation (scES), transcutaneous and transcranial magnetic neuromodulation, specifically targeting urogenital and bowel function recovery in individuals with spinal cord injury (SCI). Critical areas of interest include the optimization of stimulation parameters, the interaction between lumbosacral networks and urogenital and bowel control, and the integration of advanced technologies like dynamic human-in-the-loop systems. This topic will delve into recent breakthroughs and ongoing debates regarding the long-term efficacy and safety of central neuromodulation which include techniques such as epidural stimulation (ES), midbrain locomotor region deep brain stimulation (MLR-DBS), non-invasive transcutaneous stimulation, and transcranial magnetic stimulation. Moreover, the emphasis on personalized approaches remains strong, aiming to tailor interventions to individual needs.



This Research Topic aims to bridge current knowledge gaps and propose new pathways for clinical research and application in neuromodulation techniques. By examining the latest advancements and addressing the challenges associated with these interventions, the research will contribute to more effective and innovative treatment options for SCI patients. This endeavor seeks to enhance the understanding of the multifaceted neuromodulation methods and their implications for restoring urogenital and bowel function in SCI.



To gather further insights in the application of neuromodulation approaches targeting urogenital and bowel function, we welcome articles addressing, but not limited to, the following themes:

- Optimization and personalization of stimulation parameters in central neuromodulation

- Interaction between lumbosacral networks and urogenital and bowel control

- Incorporating dynamic human-in-the-loop systems in neuromodulation research

- Long-term efficacy and safety of combined neuromodulation strategies

- Innovative technological advancements in neuromodulation, including ES, MLR-DBS, non-invasive transcutaneous stimulation, and transcranial magnetic stimulation

- Challenges and open questions: explore the complexities and obstacles in the field, such as the impact of systemic inflammation affecting multiple organ systems, the evolving remodeling of neural circuits within the context of chronic injury, the effects of neuromodulation itself, and aging with an injury.


Authors can submit original research articles, reviews, and case studies that contribute to these themes and broaden the understanding of neuromodulation's role in urogenital and bowel control recovery.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

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Keywords: Central neuromodulation, Spinal cord epidural stimulation (scES), Transcutaneous neuromodulation, Transcranial magnetic neuromodulation, Bladder function recovery, Spinal cord injury (SCI)

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