A Accumulation | List of Frontiers open access articles

Original Research

Published on 02 Jun 2023

Uncovering neuroinflammation-related modules and potential repurposing drugs for Alzheimer's disease through multi-omics data integrative analysis

in Alzheimer's Disease and Related Dementias

Shensuo Li
Changhao Lu
Zhenzhen Zhao
Dong Lu
Guangyong Zheng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2023.1161405

5,816 views
11 citations

Original Research

Published on 27 Jun 2014

Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation

in Alzheimer's Disease and Related Dementias

Ditte Z. Christensen
Melanie Huettenrauch
Miso Mitkovski
Laurent Pradier
Oliver Wirths

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2014.00139

10,179 views
27 citations

Original Research

Published on 06 Sep 2019

SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse

in Cellular Neuropathology

Yongzhuang Xie
Mengxi Niu
Chengxiang Ji
Timothy Y. Huang
Cuilin Zhang
Ye Tian
Zhun Shi
Chen Wang
Yingjun Zhao
Hong Luo

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2019.00410

5,178 views
13 citations

Original Research

Published on 23 May 2022

Impact of APOE ε4 Carrier Status on Associations Between Subthreshold, Positive Amyloid-β Deposition, Brain Function, and Cognitive Performance in Cognitively Normal Older Adults: A Prospective Study

in Alzheimer's Disease and Related Dementias

Dong Woo Kang
Sheng-Min Wang
Yoo Hyun Um
Nak-Young Kim
Chang Uk Lee
Hyun Kook Lim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2022.871323

3,133 views
4 citations

Original Research

Published on 08 Mar 2018

Synergistic Effect on Neurodegeneration by N-Truncated Aβ4−42 and Pyroglutamate Aβ3−42 in a Mouse Model of Alzheimer's Disease

in Alzheimer's Disease and Related Dementias

Jose S. Lopez-Noguerola
Nicolai M. E. Giessen
Maximilian Ueberück
Julius N. Meißner
Charlotte E. Pelgrim
Johnathan Adams
Oliver Wirths
Yvonne Bouter
Thomas A. Bayer

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2018.00064

4,484 views
12 citations

Original Research

Published on 07 Feb 2022

Distinctive Temporal Trajectories of Alzheimer’s Disease Biomarkers According to Sex and APOE Genotype: Importance of Striatal Amyloid

in Alzheimer's Disease and Related Dementias

Jun Pyo Kim
Min Young Chun
Soo-Jong Kim
Hyemin Jang
Hee Jin Kim
Jee Hyang Jeong
Duk L. Na
Sang Won Seo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2022.829202

4,578 views
13 citations

Review

Published on 10 Mar 2010

Intracellular accumulation of amyloid-beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease

in Alzheimer's Disease and Related Dementias

Thomas A Bayer
Oliver Wirths

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2010.00008

28,524 views
229 citations

Review

Published on 31 Oct 2024

Autophagy-lysosomal pathway impairment and cathepsin dysregulation in Alzheimer’s disease

in Cellular Biochemistry

Alquiandra Stefani Ferreira Mançano
Juliana Guanaes Pina
Bruna Rojas Froes
Juliana Mozer Sciani

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1490275

6,450 views
20 citations

Original Research

Published on 07 Feb 2022

Prostacyclin Promotes Degenerative Pathology in a Model of Alzheimer’s Disease

in Non-Neuronal Cells

Tasha R. Womack
Craig T. Vollert
Odochi Ohia-Nwoko
Monika Schmitt
Saghi Montazari
Tina L. Beckett
David Mayerich
Michael Paul Murphy
Jason L. Eriksen

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2022.769347

4,350 views
7 citations

Original Research

Published on 27 Oct 2021

Large Amino Acid Mimicking Selenium-Doped Carbon Quantum Dots for Multi-Target Therapy of Alzheimer’s Disease

in Experimental Pharmacology and Drug Discovery

Xi Zhou
Shuyang Hu
Shuangling Wang
Yu Pang
Yulong Lin
Meng Li

Frontiers in Pharmacology

doi 10.3389/fphar.2021.778613

6,078 views
35 citations

Original Research

Published on 06 Oct 2021

Intracellular Lipid Accumulation and Mitochondrial Dysfunction Accompanies Endoplasmic Reticulum Stress Caused by Loss of the Co-chaperone DNAJC3

in Cellular Biochemistry

Matthew J. Jennings
Denisa Hathazi
Chi D. L. Nguyen
Benjamin Munro
Ute Münchberg
Robert Ahrends
Annette Schenck
Ilse Eidhof
Erik Freier
Matthis Synofzik

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.710247

7,204 views
21 citations

Mini Review

Published on 29 Apr 2025

The role of monocytes and macrophages in the progression of Alzheimer’s disease

in Inflammation

Wenyi Nie
Yingbin Yue
Jingqing Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1590909

6,282 views
6 citations

Original Research

Published on 23 Jul 2025

The effect of oral administration of NXP032 equivalent to intraperitoneal administration in an Alzheimer’s disease model

in Neuropharmacology

Jae Min Lee
You Jung Choi
Da-Eun Sung
Tae Hyeok Sim
So Hee Kim
Seung Geun Yeo
Youn-Jung Kim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1632640

1,737 views

Review

Published on 15 Dec 2021

Biomarkers to Evaluate Androgen Deprivation Therapy for Prostate Cancer and Risk of Alzheimer’s Disease and Neurodegeneration: Old Drugs, New Concerns

in Genitourinary Oncology

Vérane Achard
Kelly Ceyzériat
Benjamin B. Tournier
Giovanni B. Frisoni
Valentina Garibotto
Thomas Zilli

Frontiers in Oncology

doi 10.3389/fonc.2021.734881

5,552 views
9 citations

Original Research

Published on 24 Feb 2026

Exploring the pathogenic mechanisms of dementia risk factors: a task-fMRI study of mild cognitive impairment

in Neurodegeneration

Yuling Shen
Min Shi
Shanyu Liu
Yan Liu
Lijun Wang
Dongdong Yang

Frontiers in Neuroscience

doi 10.3389/fnins.2026.1751092

137 views

Review

Published on 09 Feb 2010

Oxidative stress mediates the pathogenic effect of different Alzheimer's disease risk factors

in Alzheimer's Disease and Related Dementias

Michela Guglielmotto
Luca Giliberto
Elena Tamagno
Massimo Tabaton

Frontiers in Aging Neuroscience

doi 10.3389/neuro.24.003.2010

18,669 views
131 citations

Articles

Uncovering neuroinflammation-related modules and potential repurposing drugs for Alzheimer's disease through multi-omics data integrative analysis

Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation

SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse

Impact of APOE ε4 Carrier Status on Associations Between Subthreshold, Positive Amyloid-β Deposition, Brain Function, and Cognitive Performance in Cognitively Normal Older Adults: A Prospective Study

Synergistic Effect on Neurodegeneration by N-Truncated Aβ4−42 and Pyroglutamate Aβ3−42 in a Mouse Model of Alzheimer's Disease

Distinctive Temporal Trajectories of Alzheimer’s Disease Biomarkers According to Sex and APOE Genotype: Importance of Striatal Amyloid

Intracellular accumulation of amyloid-beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease

Autophagy-lysosomal pathway impairment and cathepsin dysregulation in Alzheimer’s disease

Prostacyclin Promotes Degenerative Pathology in a Model of Alzheimer’s Disease

Large Amino Acid Mimicking Selenium-Doped Carbon Quantum Dots for Multi-Target Therapy of Alzheimer’s Disease

Intracellular Lipid Accumulation and Mitochondrial Dysfunction Accompanies Endoplasmic Reticulum Stress Caused by Loss of the Co-chaperone DNAJC3

The role of monocytes and macrophages in the progression of Alzheimer’s disease

The effect of oral administration of NXP032 equivalent to intraperitoneal administration in an Alzheimer’s disease model

Biomarkers to Evaluate Androgen Deprivation Therapy for Prostate Cancer and Risk of Alzheimer’s Disease and Neurodegeneration: Old Drugs, New Concerns

Exploring the pathogenic mechanisms of dementia risk factors: a task-fMRI study of mild cognitive impairment

Oxidative stress mediates the pathogenic effect of different Alzheimer's disease risk factors