Car Nk | List of Frontiers open access articles

Review

Published on 25 Apr 2024

Chimeric antigen receptor-natural killer cell therapy: current advancements and strategies to overcome challenges

in Cancer Immunity and Immunotherapy

Jun Chang Kong
Mohammad Auwal Sa’ad
Hema Manusri Vijayan
Manickam Ravichandran
Venugopal Balakrishnan
Seng Kong Tham
Gee Jun Tye

Frontiers in Immunology

doi 10.3389/fimmu.2024.1384039

10,546 views
27 citations

Original Research

Published on 12 Jan 2026

Construction of anti-HER2 affibody-directed CAR-NK and its synergistic effects with doxorubicin-loaded nanodrug against HER2-positive breast cancer

in NK and Innate Lymphoid Cell Biology

Xuesong He
Zhaoyuan Liang
Qing Liu
Xiaofei Zhang
Hao Liang
Runqing Jia
Wang Sheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692107

1,368 views

Perspective

Published on 19 Nov 2025

Perspective: IL-15 cytokine-armored NK cells as ready-to-use immunotherapy for diverse malignancies: therapeutic potential and toxicity risks

in NK and Innate Lymphoid Cell Biology

Scott L. Baughan
Timothy Folsom
Matt Johnson
Joshua Kreuger
Beau R. Webber
Branden S. Moriarity

Frontiers in Immunology

doi 10.3389/fimmu.2025.1704404

4,552 views
5 citations

Review

Published on 19 Jun 2023

CAR-NK cell therapy for glioblastoma: what to do next?

in Neuro-Oncology and Neurosurgical Oncology

Qi Xiong
Jiao Zhu
Yong Zhang
Hongxin Deng

Frontiers in Oncology

doi 10.3389/fonc.2023.1192128

13,090 views
32 citations

Review

Published on 11 Feb 2025

Novel gene manipulation approaches to unlock the existing bottlenecks of CAR-NK cell therapy

in Cancer Cell Biology

Fatemeh Dehghan
Yekta Metanat
Mandana Askarizadeh
Ehsan Ahmadi
Vahid Moradi

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2024.1511931

7,202 views
20 citations

Review

Published on 23 May 2025

Application and prospects of genetic engineering in CAR-NK cell therapy

in NK and Innate Lymphoid Cell Biology

Caidong Hu
Wenhong Lai
Bin Tian
Xi Xu
Shuiling Xie
Wenting Zhong
Huiqiang Kang
Xiaoyun Chen
Hailiang Li
Jingxin Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600411

6,245 views
6 citations

Review

Published on 19 Jan 2023

Clinical application and prospect of immune checkpoint inhibitors for CAR-NK cell in tumor immunotherapy

in NK and Innate Lymphoid Cell Biology

Kangdi Yang
Yuze Zhao
Guanqun Sun
Xu Zhang
Jinjin Cao
Mingcong Shao
Xijun Liang
Lina Wang

Frontiers in Immunology

doi 10.3389/fimmu.2022.1081546

8,831 views
38 citations

Original Research

Published on 30 Sep 2025

Signaling intact membrane-bound IL-15 enables potent anti-tumor activity and safety of CAR-NK cells

in Cancer Immunity and Immunotherapy

Xiaodi Xu
Peiyu Cao
Meng Wang
Yan Wan
Shuwen Sun
Yuxin Chen
Yilin Liu
Tong Su
Ge Gao
Xinze Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658580

6,074 views
5 citations

Original Research

Published on 10 Nov 2023

CD44v6 specific CAR-NK cells for targeted immunotherapy of head and neck squamous cell carcinoma

in Molecular Innate Immunity

Ioana Sonya Ciulean
Joe Fischer
Andrea Quaiser
Christoph Bach
Hinrich Abken
Uta Sandy Tretbar
Stephan Fricke
Ulrike Koehl
Dominik Schmiedel
Thomas Grunwald

Frontiers in Immunology

doi 10.3389/fimmu.2023.1290488

13,272 views
30 citations

Review

Published on 30 May 2025

CAR-NK cells: harnessing the power of natural killers for advanced cancer therapy

in Cancer Immunity and Immunotherapy

Filipa D. dos Reis
Yanis Saidani
Paula Martín-Rubio
Rebeca Sanz-Pamplona
Ana Stojanovic
Margareta P. Correia

Frontiers in Immunology

doi 10.3389/fimmu.2025.1603757

9,850 views
18 citations

Original Research

Published on 24 Jul 2024

Scalable process development of NK and CAR-NK expansion in a closed bioreactor

in NK and Innate Lymphoid Cell Biology

Xuening Wang
Maeve Elizabeth Byrne
Chang Liu
Minh Tuyet Ma
Dongfang Liu

Frontiers in Immunology

doi 10.3389/fimmu.2024.1412378

9,400 views
15 citations

Hypothesis and Theory

Published on 15 Dec 2023

Synergistic treatment strategy: combining CAR-NK cell therapy and radiotherapy to combat solid tumors

in Cancer Immunity and Immunotherapy

Jie He
Yushan Yan
Jun Zhang
Zhiming Wei
Huashun Li
Ligang Xing

Frontiers in Immunology

doi 10.3389/fimmu.2023.1298683

8,717 views
26 citations

Review

Published on 06 Aug 2021

From CAR-T Cells to CAR-NK Cells: A Developing Immunotherapy Method for Hematological Malignancies

in Cancer Immunity and Immunotherapy

Hui Lu
Xiaoyan Zhao
Ziying Li
Yu Hu
Huafang Wang

Frontiers in Oncology

doi 10.3389/fonc.2021.720501

34,065 views
115 citations

Original Research

Published on 12 Aug 2022

A bibliometric and scientific knowledge-map study of the chimeric antigen receptor (CAR) natural killer (NK) cell-related research from 2010 to 2022

in Cancer Immunity and Immunotherapy

Juan Zhang
Peng Chen
Lele Miao

Frontiers in Immunology

doi 10.3389/fimmu.2022.969196

7,774 views
13 citations

Original Research

Published on 07 Mar 2025

Entinostat, a histone deacetylase inhibitor, enhances CAR-NK cell anti-tumor activity by sustaining CAR expression

in Cancer Immunity and Immunotherapy

Dong-Hyeon Jo
Shelby Kaczmarek
Abrar Ul Haq Khan
Jannat Pervin
Diana M. Clark
Suresh Gadde
Lisheng Wang
Scott McComb
Alissa Visram
Seung-Hwan Lee

Frontiers in Immunology

doi 10.3389/fimmu.2025.1533044

6,031 views
13 citations

Original Research

Published on 11 Oct 2023

Preclinical assessment of CAR-NK cell-mediated killing efficacy and pharmacokinetics in a rapid zebrafish xenograft model of metastatic breast cancer

in NK and Innate Lymphoid Cell Biology

Nivedha Murali Shankar
Paola Ortiz-Montero
Anastasia Kurzyukova
Wiebke Rackwitz
Stephan R. Künzel
Winfried S. Wels
Torsten Tonn
Franziska Knopf
Jiri Eitler

Frontiers in Immunology

doi 10.3389/fimmu.2023.1254821

9,466 views
17 citations

Articles

Chimeric antigen receptor-natural killer cell therapy: current advancements and strategies to overcome challenges

Construction of anti-HER2 affibody-directed CAR-NK and its synergistic effects with doxorubicin-loaded nanodrug against HER2-positive breast cancer

Perspective: IL-15 cytokine-armored NK cells as ready-to-use immunotherapy for diverse malignancies: therapeutic potential and toxicity risks

CAR-NK cell therapy for glioblastoma: what to do next?

Novel gene manipulation approaches to unlock the existing bottlenecks of CAR-NK cell therapy

Application and prospects of genetic engineering in CAR-NK cell therapy

Clinical application and prospect of immune checkpoint inhibitors for CAR-NK cell in tumor immunotherapy

Signaling intact membrane-bound IL-15 enables potent anti-tumor activity and safety of CAR-NK cells

CD44v6 specific CAR-NK cells for targeted immunotherapy of head and neck squamous cell carcinoma

CAR-NK cells: harnessing the power of natural killers for advanced cancer therapy

Scalable process development of NK and CAR-NK expansion in a closed bioreactor

Synergistic treatment strategy: combining CAR-NK cell therapy and radiotherapy to combat solid tumors

From CAR-T Cells to CAR-NK Cells: A Developing Immunotherapy Method for Hematological Malignancies

A bibliometric and scientific knowledge-map study of the chimeric antigen receptor (CAR) natural killer (NK) cell-related research from 2010 to 2022

Entinostat, a histone deacetylase inhibitor, enhances CAR-NK cell anti-tumor activity by sustaining CAR expression

Preclinical assessment of CAR-NK cell-mediated killing efficacy and pharmacokinetics in a rapid zebrafish xenograft model of metastatic breast cancer