Combined Blockade | List of Frontiers open access articles

Original Research

Published on 09 Aug 2019

Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy

in Renal Pharmacology

Mengjie Jiang
Jinjin Fan
Xinli Qu
Songhui Li
Susan K. Nilsson
Yu Bo Yang Sun
Yaping Chen
Di Yu
Dan Liu
Bi-Cheng Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2019.00880

8,179 views
31 citations

Original Research

Published on 11 Feb 2025

Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer

in T Cell Biology

Lulu Zhang
Xiyuan Guo
Xiaoke Sun
Jue Liao
Qin Liu
Yingchun Ye
Zhihui Yang
Ratchada Cressey
Qing He
Qing Yuan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1486329

6,181 views
9 citations

Mini Review

Published on 21 Jan 2025

Reversing NK cell exhaustion: a novel strategy combining immune checkpoint blockade with drug sensitivity enhancement in the treatment of hepatocellular carcinoma

in Cancer Immunity and Immunotherapy

Yuxiang Huang
Hengjian Liao
Jiefu Luo
Huaning Wei
Anling Li
Yujie Lu
Bangde Xiang

Frontiers in Oncology

doi 10.3389/fonc.2024.1502270

4,580 views
5 citations

Original Research

Published on 02 Oct 2023

Immunosuppressive M2 TAMs represent a promising target population to enhance phagocytosis of ovarian cancer cells in vitro

in Cancer Immunity and Immunotherapy

Franziska Brauneck
Leticia Oliveira-Ferrer
Jana Muschhammer
Tabea Sturmheit
Christin Ackermann
Friedrich Haag
Julian Schulze zur Wiesch
Yi Ding
Minyue Qi
Louisa Hell

Frontiers in Immunology

doi 10.3389/fimmu.2023.1250258

7,138 views
18 citations

Perspective

Published on 01 Jul 2025

CTLA-4 and PD-1 combined blockade therapy for malignant melanoma brain metastases: mechanisms, challenges, and prospects

in Cancer Immunity and Immunotherapy

Jia-Wen Wang
Ying-Fa Feng
Jia-Hui Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629879

5,168 views
2 citations

Original Research

Published on 10 Jun 2021

Reversal of the CD8+ T-Cell Exhaustion Induced by Chronic HIV-1 Infection Through Combined Blockade of the Adenosine and PD-1 Pathways

in Viral Immunology

Jing Li
Hui-Huang Huang
Bo Tu
Ming-Ju Zhou
Wei Hu
Yu-Long Fu
Xiao-Yu Li
Tao Yang
Jin-Wen Song
Xing Fan

Frontiers in Immunology

doi 10.3389/fimmu.2021.687296

10,381 views
29 citations

Original Research

Published on 01 Jul 2025

Galectin-9 and Tim-3 in gastric cancer: a checkpoint axis driving T cell exhaustion and Treg-mediated immunosuppression independently of anti-PD-1 blockade

in Cancer Immunity and Immunotherapy

Charlotte N. Hill
Gabriela Maita
Camille Cabrolier
Constanza Aros
Ana Maria Vega-Letter
Pamela Gonzalez
Alexis M. Kalergis
Patricia Luz-Crawford
Gareth I. Owen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600792

6,222 views
7 citations

Review

Published on 22 Aug 2022

Molecular basis for pericyte-induced capillary tube network assembly and maturation

in Morphogenesis and Patterning

Scott S. Kemp
Prisca K. Lin
Zheying Sun
Maria A. Castaño
Ksenia Yrigoin
Marlena R. Penn
George E. Davis

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2022.943533

6,612 views
27 citations

Mini Review

Published on 22 Sep 2021

Targeting Tim-3 in Cancer With Resistance to PD-1/PD-L1 Blockade

in Cancer Molecular Targets and Therapeutics

Tian Tian
Zhaoming Li

Frontiers in Oncology

doi 10.3389/fonc.2021.731175

17,859 views
85 citations

Original Research

Published on 22 Mar 2022

Human B Cells Mediate Innate Anti-Cancer Cytotoxicity Through Concurrent Engagement of Multiple TNF Superfamily Ligands

in B Cell Biology

Bratislav M. Janjic
Aditi Kulkarni
Robert L. Ferris
Lazar Vujanovic
Nikola L. Vujanovic

Frontiers in Immunology

doi 10.3389/fimmu.2022.837842

8,764 views
21 citations

Original Research

Published on 26 Mar 2019

Expanding the Arsenal of FGFR Inhibitors: A Novel Chloroacetamide Derivative as a New Irreversible Agent With Anti-proliferative Activity Against FGFR1-Amplified Lung Cancer Cell Lines

in Cancer Molecular Targets and Therapeutics

Claudia Fumarola
Nicole Bozza
Riccardo Castelli
Francesca Ferlenghi
Giuseppe Marseglia
Alessio Lodola
Mara Bonelli
Silvia La Monica
Daniele Cretella
Roberta Alfieri

Frontiers in Oncology

doi 10.3389/fonc.2019.00179

14,957 views
45 citations

Original Research

Published on 23 Jun 2022

Role of the PD-1/PD-L1 Pathway in Experimental Trypanosoma cruzi Infection and Potential Therapeutic Options

in Parasite Immunology

Yanina Arana
Rosa Isela Gálvez
Thomas Jacobs

Frontiers in Immunology

doi 10.3389/fimmu.2022.866120

5,067 views
11 citations

Original Research

Published on 24 Dec 2021

Comparison of Necroptosis With Apoptosis for OVX-Induced Osteoporosis

in Cellular Biochemistry

Bin He
Yongjun Zhu
Hongwang Cui
Bo Sun
Tian Su
Peng Wen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2021.790613

5,380 views
24 citations

Original Research

Published on 27 Apr 2022

Immune Checkpoint Protein Expression Defines the Prognosis of Advanced Thyroid Carcinoma

in Thyroid Endocrinology

Yi Luo
Yi-Chen Yang
Cen-Kai Shen
Ben Ma
Wei-Bo Xu
Qi-Feng Wang
Yan Zhang
Tian Liao
Wen-Jun Wei
Yu Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2022.859013

6,404 views
24 citations

Original Research

Published on 27 Jul 2021

Combined Blockade of GARP:TGF-β1 and PD-1 Increases Infiltration of T Cells and Density of Pericyte-Covered GARP+ Blood Vessels in Mouse MC38 Tumors

in Cancer Immunity and Immunotherapy

Charlotte Bertrand
Pierre Van Meerbeeck
Grégoire de Streel
Noora Vaherto-Bleeckx
Fatima Benhaddi
Loïc Rouaud
Agnès Noël
Pierre G. Coulie
Nicolas van Baren
Sophie Lucas

Frontiers in Immunology

doi 10.3389/fimmu.2021.704050

15,863 views
16 citations

Articles

Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy

Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer

Reversing NK cell exhaustion: a novel strategy combining immune checkpoint blockade with drug sensitivity enhancement in the treatment of hepatocellular carcinoma

Immunosuppressive M2 TAMs represent a promising target population to enhance phagocytosis of ovarian cancer cells in vitro

CTLA-4 and PD-1 combined blockade therapy for malignant melanoma brain metastases: mechanisms, challenges, and prospects

Reversal of the CD8+ T-Cell Exhaustion Induced by Chronic HIV-1 Infection Through Combined Blockade of the Adenosine and PD-1 Pathways

Galectin-9 and Tim-3 in gastric cancer: a checkpoint axis driving T cell exhaustion and Treg-mediated immunosuppression independently of anti-PD-1 blockade

Molecular basis for pericyte-induced capillary tube network assembly and maturation

Targeting Tim-3 in Cancer With Resistance to PD-1/PD-L1 Blockade

Human B Cells Mediate Innate Anti-Cancer Cytotoxicity Through Concurrent Engagement of Multiple TNF Superfamily Ligands

Expanding the Arsenal of FGFR Inhibitors: A Novel Chloroacetamide Derivative as a New Irreversible Agent With Anti-proliferative Activity Against FGFR1-Amplified Lung Cancer Cell Lines

Role of the PD-1/PD-L1 Pathway in Experimental Trypanosoma cruzi Infection and Potential Therapeutic Options

Comparison of Necroptosis With Apoptosis for OVX-Induced Osteoporosis

Immune Checkpoint Protein Expression Defines the Prognosis of Advanced Thyroid Carcinoma

Combined Blockade of GARP:TGF-β1 and PD-1 Increases Infiltration of T Cells and Density of Pericyte-Covered GARP+ Blood Vessels in Mouse MC38 Tumors