Downstaging | List of Frontiers open access articles

Review

Published on 18 Nov 2021

Downstaging Conversion Therapy in Patients With Initially Unresectable Advanced Hepatocellular Carcinoma: An Overview

in Surgical Oncology

Hui-Chuan Sun
Xiao-Dong Zhu

Frontiers in Oncology

doi 10.3389/fonc.2021.772195

10,518 views
52 citations

Original Research

Published on 02 Aug 2021

Combination of Sorafenib, Camrelizumab, Transcatheter Arterial Chemoembolization, and Stereotactic Body Radiation Therapy as a Novel Downstaging Strategy in Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Case Series Study

in Pharmacology of Anti-Cancer Drugs

Yun Huang
Zeyu Zhang
Weijun Liao
Kuan Hu
Zhiming Wang

Frontiers in Oncology

doi 10.3389/fonc.2021.650394

5,802 views
30 citations

Original Research

Published on 19 Nov 2021

Downstaging Therapies for Unresectable Hepatocellular Carcinoma Prior to Hepatic Resection: A Systematic Review and Meta-Analysis

in Surgical Oncology

Xinyu Chen
Lin Lai
Jiazhou Ye
Lequn Li

Frontiers in Oncology

doi 10.3389/fonc.2021.740762

7,455 views
22 citations

Original Research

Published on 12 Jun 2023

The role of MRI after neochemoradiotherapy in predicting pathological tumor regression grade and clinical outcome in patients with locally advanced rectal adenocarcinoma

in Gastrointestinal Cancers: Colorectal Cancer

Shaoqing Niu
Yan Chen
Fang Peng
Jie Wen
Jianqi Xiong
Zhuangzhuang Yang
Jianjun Peng
Yong Bao
Li Ding

Frontiers in Oncology

doi 10.3389/fonc.2023.1118518

3,875 views
7 citations

Review

Published on 08 Oct 2025

The role of radiological interventions in hepatocellular carcinoma before liver transplantation: a surgical perspective

in Visceral Surgery

Altan Alim
Derek DuBay

Frontiers in Surgery

doi 10.3389/fsurg.2025.1594579

1,278 views

Original Research

Published on 18 Sep 2018

The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging

in Cancer Endocrinology

Claudio Casella
Silvia Ministrini
Alessandro Galani
Francesco Mastriale
Carlo Cappelli
Nazario Portolani

Frontiers in Endocrinology

doi 10.3389/fendo.2018.00541

15,959 views
26 citations

Original Research

Published on 08 Apr 2021

Safety and Efficacy of Degradable Starch Microspheres Transcatheter Arterial Chemoembolization (DSM-TACE) in the Downstaging of Intermediate-Stage Hepatocellular Carcinoma (HCC) in Patients With a Child-Pugh Score of 8-9

in Drugs Outcomes Research and Policies

Roberto Minici
Michele Ammendola
Francesco Manti
Maria Anna Siciliano
Marco Minici
Iman Komaei
Giuseppe Currò
Domenico Laganà

Frontiers in Pharmacology

doi 10.3389/fphar.2021.634087

5,676 views
27 citations

Original Research

Published on 20 Nov 2024

Body composition: a crucial factor in downstaging and postoperative complications of neoadjuvant chemotherapy for gastric cancer

in Clinical Nutrition

Zhuanmei Jin
Min Chen
Qinglin Yang
Changyu Yao
Yanting Li
Taohua Zhang
Min Lai
Shuangxi Li
Lipeng Ding
Wenzhen Yuan

Frontiers in Nutrition

doi 10.3389/fnut.2024.1481365

1,984 views

Original Research

Published on 11 Jan 2024

Downstaging and laparoscopic hepatectomy plus intraoperative radiofrequency ablation for the treatment of initially unresectable multifocal hepatocellular carcinomas

in Surgical Oncology

Jianjun Wang
Hua Luo
Long Yi
Pei Yang
Xintao Zeng

Frontiers in Surgery

doi 10.3389/fsurg.2023.1340657

3,078 views
2 citations

Original Research

Published on 16 Sep 2025

Efficacy and survival analysis of neoadjuvant chemotherapy combined with immunotherapy in locally advanced resectable Siewert type II adenocarcinoma of the esophagogastric junction

in Gastrointestinal Cancers: Gastric and Esophageal Cancers

Chunyue Gai
Huilai Lv
Cuili Feng
Xiaohan Zhao
Hao Wang
Bokang Sun
Fan Zhang
Ziqiang Tian

Frontiers in Oncology

doi 10.3389/fonc.2025.1642996

1,869 views

Original Research

Published on 28 Apr 2022

Osimertinib as Neoadjuvant Therapy for Resectable Non-Small Cell Lung Cancer: A Case Series

in Pharmacology of Anti-Cancer Drugs

Yan Hu
Siying Ren
Lulu Yang
Zhongyi Tong
Ruoyao Wang
Wei Han
Chao Zeng
Jina Li
Peng Xiao
Li Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.912153

6,093 views
11 citations

Brief Research Report

Published on 10 Feb 2022

Use of Pralsetinib as Neoadjuvant Therapy for Non-Small Cell Lung Cancer Patient With RET Rearrangement

in Thoracic Oncology

Ning Zhou
Tong Li
Maoli Liang
Fan Ren
Hong Ni
Wei Liu
Tao Shi
Dongbo Xu
Qiusong Chen
Haonan Yu

Frontiers in Oncology

doi 10.3389/fonc.2022.848779

5,167 views
17 citations

Original Research

Published on 01 Nov 2024

Efficacy and safety analysis of neoadjuvant chemotherapy combined with immunotherapy in patients with muscle-invasive bladder cancer

in Cancer Immunity and Immunotherapy

Yanhang Yu
Chuanao Zhang
Hao Chen
Jianglei Zhang
Jun Ouyang

Frontiers in Immunology

doi 10.3389/fimmu.2024.1479743

2,710 views
2 citations

Case Report

Published on 16 Jul 2020

Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy

in Thoracic Oncology

Jingpei Li
Ke Xu
Weipeng Cai
Yalei Zhang
Xin Zeng
Fei Cui
Zhexue Hao
Jun Liu
Jianxing He

Frontiers in Oncology

doi 10.3389/fonc.2020.01145

3,637 views
1 citation

Case Report

Published on 16 Feb 2026

Stage IIIB ROS1-Positive NSCLC management: crizotinib + surgery + TCM achieves exceptionally prolonged PFS (a case report)

in Pharmacology of Anti-Cancer Drugs

Yu Zhu
Hao Zhang
Zheng-xiang Han
Xu Zhu
Wan-ting Wang
Huai-yang Li
Shudong Zhu
Wei Shao

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1693269

452 views

Review

Published on 20 Jan 2023

Radiation therapy in the era of immune treatment for hepatocellular carcinoma

in Cancer Immunity and Immunotherapy

Lingjuan Chen
Ruiguang Zhang
Zhenyu Lin
Qiaoyun Tan
Zhiyong Huang
Binyong Liang

Frontiers in Immunology

doi 10.3389/fimmu.2023.1100079

8,602 views
19 citations

Articles

Downstaging Conversion Therapy in Patients With Initially Unresectable Advanced Hepatocellular Carcinoma: An Overview

Combination of Sorafenib, Camrelizumab, Transcatheter Arterial Chemoembolization, and Stereotactic Body Radiation Therapy as a Novel Downstaging Strategy in Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Case Series Study

Downstaging Therapies for Unresectable Hepatocellular Carcinoma Prior to Hepatic Resection: A Systematic Review and Meta-Analysis

The role of MRI after neochemoradiotherapy in predicting pathological tumor regression grade and clinical outcome in patients with locally advanced rectal adenocarcinoma

The role of radiological interventions in hepatocellular carcinoma before liver transplantation: a surgical perspective

The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging

Safety and Efficacy of Degradable Starch Microspheres Transcatheter Arterial Chemoembolization (DSM-TACE) in the Downstaging of Intermediate-Stage Hepatocellular Carcinoma (HCC) in Patients With a Child-Pugh Score of 8-9

Body composition: a crucial factor in downstaging and postoperative complications of neoadjuvant chemotherapy for gastric cancer

Downstaging and laparoscopic hepatectomy plus intraoperative radiofrequency ablation for the treatment of initially unresectable multifocal hepatocellular carcinomas

Efficacy and survival analysis of neoadjuvant chemotherapy combined with immunotherapy in locally advanced resectable Siewert type II adenocarcinoma of the esophagogastric junction

Osimertinib as Neoadjuvant Therapy for Resectable Non-Small Cell Lung Cancer: A Case Series

Use of Pralsetinib as Neoadjuvant Therapy for Non-Small Cell Lung Cancer Patient With RET Rearrangement

Efficacy and safety analysis of neoadjuvant chemotherapy combined with immunotherapy in patients with muscle-invasive bladder cancer

Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy

Stage IIIB ROS1-Positive NSCLC management: crizotinib + surgery + TCM achieves exceptionally prolonged PFS (a case report)

Radiation therapy in the era of immune treatment for hepatocellular carcinoma