Drug Design And Development | List of Frontiers open access articles

Original Research

Published on 06 Oct 2025

Immune regulatory mechanisms of M2 macrophage polarization and efferocytosis in diabetic kidney disease: an integrated screening study with therapeutic implications

in Renal Endocrinology

Yi Kang
Qian Jin
Mengqi Zhou
Huijuan Zheng
Danwen Li
Xuezhe Wang
Jingwei Zhou
Jie Lv
Yaoxian Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1652402

357 views

Core Concept

Published on 06 Oct 2025

Solving Cystic Fibrosis: From lab Bench to Bedside

in Human Health

Michael J. Welsh
Paul Negulescu

Frontiers for Young Minds

doi 10.3389/frym.2025.1650140

197 views

Original Research

Published on 06 Oct 2025

Generalised machine learning models outperform personalised models for cognitive load classification in real-life settings

in Digital Mental Health

Christoph Anders
Ipsita Bhaduri
Bert Arnrich

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1650085

896 views

Original Research

Published on 06 Oct 2025

Within-reef biomass partitioning in a Mediterranean vermetid reef: a baseline for future monitoring

in Marine Biology

Francesco Paolo Mancuso
Luca Bisanti
Flavio Picone
Renato Chemello

Frontiers in Marine Science

doi 10.3389/fmars.2025.1656826

907 views

Original Research

Published on 06 Oct 2025

Prediction of lymphovascular invasion in non-mass enhancement breast cancer using DCE-MRI and clinical-pathological features

in Breast Cancer

Shiqi Guo
Kai Zhao
Hu Xu
Yujiao Xie
Qingyang Li
Junqing Liang
Siyi Chen
Jiahong Sun
Zhaofeng Gao
Li Zhu

Frontiers in Oncology

doi 10.3389/fonc.2025.1539748

318 views

Systematic Review

Published on 06 Oct 2025

Precision agriculture techniques for optimizing chemical fertilizer use and environmental sustainability: a systematic review

in Agroecological Cropping Systems

Baozhong Cai
Fang Shi
Betelhem A. Geremew
Amsalu K. Addis
Meseret C. Abate
Wubliker Dessie
Tesfaye Bayu

Frontiers in Agronomy

doi 10.3389/fagro.2025.1665444

582 views

Review

Published on 06 Oct 2025

Unspoken words: decoding the dialog between type 2 innate lymphoid cells and T cells

in NK and Innate Lymphoid Cell Biology

Zahra Jamila Ikra
Qiutong Huang
Huiyang Yu
Gabrielle T. Belz
Craig N. Jenne
Nicolas Jacquelot

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677358

3,023 views

Original Research

Published on 06 Oct 2025

Sex differences in the effects of mental fatigue on single-leg drop landing biomechanics among sport science university students

in Sport Psychology

Zilong Wang
Ziqi Feng
Huizi Cui
Lingyue Meng
Pengfei Wang
Mengya Lu
Tao Liu
Qiuxia Zhang
Xiangdong Wang

Frontiers in Psychology

doi 10.3389/fpsyg.2025.1678338

670 views

Original Research

Published on 06 Oct 2025

Isolation and genetic characterization of a novel recombinant HP-PRRSV strain in Jiangxi Province, China

in Veterinary Infectious Diseases

Chenyi Wang
Ruoming Li
Jiajia Chen
Meiling Zhuo
Qi Peng
Lingbao Kong
Ting Wang

Frontiers in Veterinary Science

doi 10.3389/fvets.2025.1678378

360 views

Original Research

Published on 06 Oct 2025

What agenda of and for women? Gender, politics, and institutional transformation in Rome

in Elections and Representation

Fatima Farina

Frontiers in Political Science

doi 10.3389/fpos.2025.1674925

420 views

Brief Research Report

Published on 06 Oct 2025

A high eosinophil proportion increases the risk of skin-related adverse events induced by apalutamide in patients with prostate cancer

in Cancer Immunity and Immunotherapy

Yoshihiko Tasaki
Taku Naiki
Yoshihisa Mimura
Yosuke Sugiyama
Misato Tomita
Toshiharu Morikawa
Takashi Nagai
Rei Unno
Toshiki Etani
Shuzo Hamamoto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1681734

272 views

Original Research

Published on 06 Oct 2025

Multi-omics integration reveals organ-specific biosynthesis of flavonoids and terpenoids in the medicinal plant Bidens alba

in Plant Metabolism and Chemodiversity

Zhaochu Wang
Xinyu Xu
Peilan Zhang
Ye Huang
Chenzi Zhao
Yousry A. El-Kassaby
Yangtao Chen
Jing Wang
Rong Shi

Frontiers in Plant Science

doi 10.3389/fpls.2025.1675432

447 views

Original Research

Published on 06 Oct 2025

Implications of cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy on hippocampal-dependent cognition and gut microbiome

in Host and Microbe Associations

Christa Corley
Chase Swinton
Taylor McElory
Bhavana Sridharan
Justin Thomas
Bailey Cronin
Vijayalakshmi Sridharan
Michael S. Robeson
Antiño R. Allen

Frontiers in Microbiomes

doi 10.3389/frmbi.2025.1486757

361 views

Review

Published on 06 Oct 2025

Nitrogen waste metabolism as a locus of nitrergic co-transmission in the brain

in Motivation and Reward

Joseph L. Bedont

Frontiers in Behavioral Neuroscience

doi 10.3389/fnbeh.2025.1537975

1,191 views

Original Research

Published on 06 Oct 2025

Youth in times of polycrises: the role of social support in connection with the depression and anxiety symptoms among young people in polish secondary schools during the COVID-19 threat and the outbreak of war in Ukraine

in Personality and Social Psychology

Karina Badura-Brzoza
Patryk Główczyński
Dominika Tatar
Paweł Dębski

Frontiers in Psychology

doi 10.3389/fpsyg.2025.1591218

10,465 views

Original Research

Published on 06 Oct 2025

Th9 cells provide protective TB immunity

in Microbial Immunology

Mei Xia
Azra Blazevic
Huan Ning
Christopher S. Eickhoff
Chad E. Storer
Richard D. Head
Jianguo Liu
Jessica Jarvela
David Stoeckel
Erin Rakey

Frontiers in Immunology

doi 10.3389/fimmu.2025.1581286

439 views

Articles

Immune regulatory mechanisms of M2 macrophage polarization and efferocytosis in diabetic kidney disease: an integrated screening study with therapeutic implications

Solving Cystic Fibrosis: From lab Bench to Bedside

Generalised machine learning models outperform personalised models for cognitive load classification in real-life settings

Within-reef biomass partitioning in a Mediterranean vermetid reef: a baseline for future monitoring

Prediction of lymphovascular invasion in non-mass enhancement breast cancer using DCE-MRI and clinical-pathological features

Precision agriculture techniques for optimizing chemical fertilizer use and environmental sustainability: a systematic review

Unspoken words: decoding the dialog between type 2 innate lymphoid cells and T cells

Sex differences in the effects of mental fatigue on single-leg drop landing biomechanics among sport science university students

Isolation and genetic characterization of a novel recombinant HP-PRRSV strain in Jiangxi Province, China

What agenda of and for women? Gender, politics, and institutional transformation in Rome

A high eosinophil proportion increases the risk of skin-related adverse events induced by apalutamide in patients with prostate cancer

Multi-omics integration reveals organ-specific biosynthesis of flavonoids and terpenoids in the medicinal plant Bidens alba

Implications of cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy on hippocampal-dependent cognition and gut microbiome

Nitrogen waste metabolism as a locus of nitrergic co-transmission in the brain

Youth in times of polycrises: the role of social support in connection with the depression and anxiety symptoms among young people in polish secondary schools during the COVID-19 threat and the outbreak of war in Ukraine

Th9 cells provide protective TB immunity