Early Onset Ad | List of Frontiers open access articles

Original Research

Published on 28 Jun 2017

Cerebrospinal Fluid Aβ43 Is Reduced in Early-Onset Compared to Late-Onset Alzheimer’s Disease, But Has Similar Diagnostic Accuracy to Aβ42

in Alzheimer's Disease and Related Dementias

Camilla Lauridsen
Sigrid B. Sando
Ina Møller
Guro Berge
Precious K. Pomary
Gøril R. Grøntvedt
Øyvind Salvesen
Geir Bråthen
Linda R. White

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2017.00210

6,536 views
25 citations

Original Research

Published on 14 May 2012

Differences between Early and Late-Onset Alzheimer’s Disease in Neuropsychological Tests

in Ageing

Francisca Sá
Paula Pinto
Catarina Cunha
Raquel Lemos
Liliana Letra
Mário Simões
Isabel Santana

Frontiers in Neurology

doi 10.3389/fneur.2012.00081

34,055 views
63 citations

Case Report

Published on 03 Nov 2022

Case analysis of early-onset Alzheimer's disease associated with TBK1 p.Tyr235Phe gene mutation

in Dementia and Neurodegenerative Diseases

Pan Li
Yuanyuan Y
Hao Cai
Huihong Zhang
Yuying Zhou

Frontiers in Neurology

doi 10.3389/fneur.2022.993399

3,222 views
1 citation

Review

Published on 06 Oct 2017

Alzheimer’s Disease: From Genetic Variants to the Distinct Pathological Mechanisms

in Brain Disease Mechanisms

Qiying Sun
Nina Xie
Beisha Tang
Rena Li
Yong Shen

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2017.00319

17,561 views
45 citations

Original Research

Published on 16 Feb 2026

Behavioral deficits and exacerbated neural and hemodynamic odor responses during lifespan of a mouse model of late onset Alzheimer’s disease expressing humanized APOEε4 and Trem2*R47H

in Alzheimer's Disease and Related Dementias

Misha Izydorczak
Maggie Oumov
Mansiben V. Udhwani
Faysal Fostok
Guillermo Coronas-Samano
Basavaraju G. Sanganahalli
Peter Herman
Fahmeed Hyder
Justus V. Verhagen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1622135

133 views

Original Research

Published on 07 Jul 2025

Quantitative analysis of targeted lipidomics in the hippocampus of APP/PS1 mice employing the UHPLC-MS/MS method

in Alzheimer's Disease and Related Dementias

Shiyu Xiao
Xuemeng Wei
Bing Han
Xiaoqian Shi
Congzhen Wei
Rumeng Liang
Jingna Sun
Zheng Zhang
Zhengang Han
Li Shen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1561831

3,401 views
2 citations

Original Research

Published on 16 Feb 2021

Effects of Alzheimer’s and Vascular Pathologies on Structural Connectivity in Early- and Late-Onset Alzheimer’s Disease

in Neurodegeneration

Wha Jin Lee
Cindy W. Yoon
Sung-Woo Kim
Hye Jin Jeong
Seongho Seo
Duk L. Na
Young Noh
Joon-Kyung Seong

Frontiers in Neuroscience

doi 10.3389/fnins.2021.606600

5,467 views
11 citations

Original Research

Published on 28 Jan 2021

Microglial Hyperreactivity Evolved to Immunosuppression in the Hippocampus of a Mouse Model of Accelerated Aging and Alzheimer’s Disease Traits

in Alzheimer's Disease and Related Dementias

Patricia Molina-Martínez
Rubén Corpas
Elisa García-Lara
Marta Cosín-Tomás
Rosa Cristòfol
Perla Kaliman
Carme Solà
José Luis Molinuevo
Raquel Sánchez-Valle
Anna Antonell

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.622360

6,420 views
19 citations

Review

Published on 06 Oct 2022

Novel molecular mechanisms in Alzheimer’s disease: The potential role of DEK in disease pathogenesis

in Neurocognitive Aging and Behavior

Allie N. Greene
Matia B. Solomon
Lisa M. Privette Vinnedge

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2022.1018180

7,130 views
6 citations

Original Research

Published on 27 Jun 2025

Identification and analysis of cuproptosis associated molecular clusters and immunological profiles in atopic dermatitis

in Systems Immunology

Liangzhe Wang
Bo Wang
Min Peng
Xiaoyan Yang
Sijia Huang
Ruixin Wang
Lin Du
Ruiqian Yao
Wei Wang
Baiping Dong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1545457

3,395 views
1 citation

Original Research

Published on 28 Apr 2014

Lack of C9orf72 Repeat Expansion in Taiwanese Patients with Mixed Neurodegenerative Disorders

in Neurodegeneration

Chin-Hsien Lin
Ta-Fu Chen
Ming-Jang Chiu
Han-I Lin
Ruey-Meei Wu

Frontiers in Neurology

doi 10.3389/fneur.2014.00059

4,672 views
16 citations

Systematic Review

Published on 22 Jul 2022

PSEN1 c.1292C

in Alzheimer's Disease and Related Dementias

Maribel Orozco-Barajas
Yulisa Oropeza-Ruvalcaba
Alejandro A. Canales-Aguirre
Victor J. Sánchez-González

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2022.860529

7,250 views
9 citations

Original Research

Published on 16 May 2022

Eye-Tracking Metrics for Figure-Copying Processes in Early- vs. Late-Onset Alzheimer's Disease

in Dementia and Neurodegenerative Diseases

Ko Woon Kim
Jongdoo Choi
Juhee Chin
Byung Hwa Lee
Duk L. Na

Frontiers in Neurology

doi 10.3389/fneur.2022.844341

4,385 views
12 citations

Original Research

Published on 24 Jun 2022

Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice

in Alzheimer's Disease and Related Dementias

Adrian L. Oblak
Kevin P. Kotredes
Ravi S. Pandey
Alaina M. Reagan
Cynthia Ingraham
Bridget Perkins
Christopher Lloyd
Deborah Baker
Peter B. Lin
Disha M. Soni

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2022.886575

8,957 views
21 citations

Original Research

Published on 04 Dec 2025

Peripheral CHI3L1 expression is associated with APOE ε4 status in early-onset Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Anja Steinmaurer
Lina Breit
Elisabeth Stögmann
Theresa König

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1730319

1,546 views

Original Research

Published on 09 Jan 2023

CSF biomarkers for early-onset Alzheimer's disease in Chinese population from PUMCH dementia cohort

in Neurological Biomarkers

Dan Lei
Chenhui Mao
Jie Li
Xinying Huang
Longze Sha
Caiyan Liu
Liling Dong
Qi Xu
Jing Gao

Frontiers in Neurology

doi 10.3389/fneur.2022.1030019

3,443 views
13 citations

Articles

Cerebrospinal Fluid Aβ43 Is Reduced in Early-Onset Compared to Late-Onset Alzheimer’s Disease, But Has Similar Diagnostic Accuracy to Aβ42

Differences between Early and Late-Onset Alzheimer’s Disease in Neuropsychological Tests

Case analysis of early-onset Alzheimer's disease associated with TBK1 p.Tyr235Phe gene mutation

Alzheimer’s Disease: From Genetic Variants to the Distinct Pathological Mechanisms

Behavioral deficits and exacerbated neural and hemodynamic odor responses during lifespan of a mouse model of late onset Alzheimer’s disease expressing humanized APOEε4 and Trem2*R47H

Quantitative analysis of targeted lipidomics in the hippocampus of APP/PS1 mice employing the UHPLC-MS/MS method

Effects of Alzheimer’s and Vascular Pathologies on Structural Connectivity in Early- and Late-Onset Alzheimer’s Disease

Microglial Hyperreactivity Evolved to Immunosuppression in the Hippocampus of a Mouse Model of Accelerated Aging and Alzheimer’s Disease Traits

Novel molecular mechanisms in Alzheimer’s disease: The potential role of DEK in disease pathogenesis

Identification and analysis of cuproptosis associated molecular clusters and immunological profiles in atopic dermatitis

Lack of C9orf72 Repeat Expansion in Taiwanese Patients with Mixed Neurodegenerative Disorders

PSEN1 c.1292C

Eye-Tracking Metrics for Figure-Copying Processes in Early- vs. Late-Onset Alzheimer's Disease

Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice

Peripheral CHI3L1 expression is associated with APOE ε4 status in early-onset Alzheimer’s disease

CSF biomarkers for early-onset Alzheimer's disease in Chinese population from PUMCH dementia cohort