Hard Problems | List of Frontiers open access articles

Brief Research Report

Published on 05 Mar 2026

Clinical, laboratory, and histopathological characteristics of pediatric lupus nephritis: a retrospective study in a national referral center in Mexico

in Pediatric Rheumatology

Héctor Menchaca-Aguayo
Abril Bernabe-Jiménez
Karla Chacón-Abril
Enrique Faugier-Fuentes

Frontiers in Pediatrics

doi 10.3389/fped.2026.1743610

306 views

Case Report

Published on 05 Mar 2026

Case Report: Application of multimodal imaging in the diagnosis and treatment evaluation of primary cardiac lymphoma

in Cardio-Oncology

Hanxing Shi
Jing Liang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1732686

117 views

Original Research

Published on 05 Mar 2026

Disease burden, treatment experiences and preferences in patients with acromegaly: a qualitative study

in Pituitary Endocrinology

Jennifer Quinn
Andrea De Palma
Rebecca McKeown
Rocco Adiutori
Charlotte E. Kosmas
Isabelle Petit

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1733510

195 views

Systematic Review

Published on 05 Mar 2026

Biopsychosocial approach in cardiological care: a scoping review of integrated treatments for personalized patient care

in Cardiovascular Nursing

Dina Di Giacomo
Enrica Cogodi
Lucrezia Piermarini
Antonio Scarà
Claudio Ferri
Luigi Sciarra
Silvio Romano

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1727783

393 views

Original Research

Published on 05 Mar 2026

IncRNAs transcriptomics elucidates the potential mechanism of Naoshuantong capsule in alleviating synaptic dysfunction in a murine model of cerebral ischemia/reperfusion injury

in Ethnopharmacology

Ke Song
Hongrui Zhang
Haoqi Liu
Yuanyuan Li
Yikun Sun
Xinglu Dong
Chenxi Tao
Yannan He
Zhenhong Liu
Yonghong Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1722930

244 views

Original Research

Published on 05 Mar 2026

Self-perceived loneliness on cognitive functioning and on self-perceived cognitive abilities in aging

in Geriatric Medicine

Sonia Montemurro
Radu Valentin Camenita
Giulia Sebastianutto
Massimo Nucci
Sara Mondini

Frontiers in Medicine

doi 10.3389/fmed.2026.1725659

119 views

Policy and Practice Reviews

Published on 05 Mar 2026

Measuring climate action beyond commitments: a nationally determined contributions implementation index for Africa

in Climate Law and Policy

Nicholas Ozor
Alfred Nyambane
Wentland Muhatiah

Frontiers in Climate

doi 10.3389/fclim.2026.1746338

148 views

Mini Review

Published on 05 Mar 2026

Fatty acid–related immune network in psoriasis: metabolic regulation of innate and adaptive immunity

in Experimental Pharmacology and Drug Discovery

Pengfei Wen
Xiaoxue Zhuo
Siliang Xue

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1731683

182 views

Original Research

Published on 05 Mar 2026

Body-weight supported treadmill or total body recumbent stepper for mobility-adapted cardiopulmonary exercise testing in multiple sclerosis patients with varying disability

in Rehabilitation in Neurological Conditions

Saman Hadjizadeh Anvar
Liam P. Kelly
Caitlin Newell
Lynsey Alcock
Hamidreza Barzegarpoor
Michelle Ploughman

Frontiers in Rehabilitation Sciences

doi 10.3389/fresc.2026.1731215

132 views

Systematic Review

Published on 05 Mar 2026

The effect of neo-adjuvant chemotherapy with 5-fluorouracil on the integrity of colonic anastomoses: a systematic review and meta-analysis of experimental studies on rats

in Colorectal and Proctological Surgery

Tatiana Chernyshenko
Roman Polkin
Maksat Ashyrov
Valeriy Shepelev
Roman Goncharuk

Frontiers in Surgery

doi 10.3389/fsurg.2026.1737152

160 views

Case Report

Published on 05 Mar 2026

Case Report: Stage-by-stage fueling, glucose dynamics, and next-day metabolism and biomarker responses after baseline testing in an 18.5-hour Swedish classic tetrathlon

in Sport and Exercise Nutrition

Jonny Trinh
Fredrik Edin
Ulrika Andersson-Hall
Stefan Pettersson

Frontiers in Sports and Active Living

doi 10.3389/fspor.2026.1733702

247 views

Original Research

Published on 05 Mar 2026

Altitude modulates growth and bioactive compounds in two Gastrodia elata forms through the microenvironment and soil microbes

in Plant Symbiotic Interactions

Haixin Diao
Daichuan Pan
Junfei Wang
Shunxing Guo

Frontiers in Plant Science

doi 10.3389/fpls.2026.1734174

387 views

Systematic Review

Published on 05 Mar 2026

Effects of augmented and virtual reality-based interventions on social behaviors in children with ADHD: a narrative systematic review

in Virtual Reality and Human Behaviour

Hatice Yalçın
Nilgün Sarp

Frontiers in Virtual Reality

doi 10.3389/frvir.2026.1737227

307 views

Original Research

Published on 05 Mar 2026

Improved random coincidence estimation including triple coincidence detection in PET

in Physics and Data Analysis

Debora Niekämper
Jürgen J. Scheins
Elisabeth Pfaehler
Joaquin L. Herraiz
N. Jon Shah
Christoph Lerche

Frontiers in Nuclear Medicine

doi 10.3389/fnume.2026.1739575

253 views

Study Protocol

Published on 05 Mar 2026

A novel virtual reality-integrated multi-modal intervention for community-dwelling older adults with mild cognitive impairment: protocol for a randomized controlled trial

in Alzheimer's Disease and Related Dementias

Yuanbao Sun
Zhuorong Zi
Songli Wang
Minghui Weng
Jin Peng
Linwan Liu
Jian Zhou
Nianjie Wang
Bo Liu
Kezhi Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1721346

Original Research

Published on 05 Mar 2026

Trends and disparities in bone cancer mortality among US adults from 1999 to 2020: a joinpoint regression analysis based on the CDC WONDER database

in Cancer Epidemiology and Prevention

Lei Wei
Yinghu Deng
Zhixiang Ma
Xiaosi Zhang

Frontiers in Oncology

doi 10.3389/fonc.2026.1718354

Articles

Clinical, laboratory, and histopathological characteristics of pediatric lupus nephritis: a retrospective study in a national referral center in Mexico

Case Report: Application of multimodal imaging in the diagnosis and treatment evaluation of primary cardiac lymphoma

Disease burden, treatment experiences and preferences in patients with acromegaly: a qualitative study

Biopsychosocial approach in cardiological care: a scoping review of integrated treatments for personalized patient care

IncRNAs transcriptomics elucidates the potential mechanism of Naoshuantong capsule in alleviating synaptic dysfunction in a murine model of cerebral ischemia/reperfusion injury

Self-perceived loneliness on cognitive functioning and on self-perceived cognitive abilities in aging

Measuring climate action beyond commitments: a nationally determined contributions implementation index for Africa

Fatty acid–related immune network in psoriasis: metabolic regulation of innate and adaptive immunity

Body-weight supported treadmill or total body recumbent stepper for mobility-adapted cardiopulmonary exercise testing in multiple sclerosis patients with varying disability

The effect of neo-adjuvant chemotherapy with 5-fluorouracil on the integrity of colonic anastomoses: a systematic review and meta-analysis of experimental studies on rats

Case Report: Stage-by-stage fueling, glucose dynamics, and next-day metabolism and biomarker responses after baseline testing in an 18.5-hour Swedish classic tetrathlon

Altitude modulates growth and bioactive compounds in two Gastrodia elata forms through the microenvironment and soil microbes

Effects of augmented and virtual reality-based interventions on social behaviors in children with ADHD: a narrative systematic review

Improved random coincidence estimation including triple coincidence detection in PET

A novel virtual reality-integrated multi-modal intervention for community-dwelling older adults with mild cognitive impairment: protocol for a randomized controlled trial

Trends and disparities in bone cancer mortality among US adults from 1999 to 2020: a joinpoint regression analysis based on the CDC WONDER database