In Vitro Test | List of Frontiers open access articles

Mini Review

Published on 09 Apr 2020

Cell Culture Based in vitro Test Systems for Anticancer Drug Screening

in Nanobiotechnology

Kristina V. Kitaeva
Catrin S. Rutland
Albert A. Rizvanov
Valeriya V. Solovyeva

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.00322

75,524 views
131 citations

Perspective

Published on 09 Nov 2023

Advancing chemical safety assessment through an omics-based characterization of the test system-chemical interaction

in Nanotoxicology

Giusy del Giudice
Giorgia Migliaccio
Nicoletta D’Alessandro
Laura Aliisa Saarimäki
Marcella Torres Maia
Maria Emilia Annala
Jenni Leppänen
Lena Mӧbus
Alisa Pavel
Maaret Vaani

Frontiers in Toxicology

doi 10.3389/ftox.2023.1294780

4,232 views
9 citations

Original Research

Published on 11 Sep 2025

SRC is a potential target of Arctigenin in treating triple-negative breast cancer: based on machine learning algorithms, molecular modeling and in Vitro test

in Biological Modeling and Simulation

Yuezhou Huang
Qing Luo
Linfeng Li
Tianping Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1644169

3,198 views

Original Research

Published on 27 Sep 2018

Aloe Polysaccharides Inhibit Influenza A Virus Infection—A Promising Natural Anti-flu Drug

in Virology

Zhenhong Sun
Cuilian Yu
Wei Wang
Guangfu Yu
Tingting Zhang
Lin Zhang
Jiguo Zhang
Kai Wei

Frontiers in Microbiology

doi 10.3389/fmicb.2018.02338

23,067 views
49 citations

Review

Published on 17 May 2023

New approach methods to improve human health risk assessment of thyroid hormone system disruption–a PARC project

in Developmental and Reproductive Toxicology

Louise Ramhøj
Marta Axelstad
Yoni Baert
Ana I. Cañas-Portilla
Frédéric Chalmel
Lars Dahmen
Antonio De La Vieja
Bertrand Evrard
Ann-Cathrin Haigis
Timo Hamers

Frontiers in Toxicology

doi 10.3389/ftox.2023.1189303

7,685 views
32 citations

Review

Published on 09 Aug 2019

Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

in Cardiovascular and Smooth Muscle Pharmacology

Brian D. Guth
Michael Engwall
Sandy Eldridge
C. Michael Foley
Liang Guo
Gary Gintant
John Koerner
Stanley T. Parish
Jennifer B. Pierson
Alexandre J. S. Ribeiro

Frontiers in Pharmacology

doi 10.3389/fphar.2019.00884

8,110 views
26 citations

Original Research

Published on 27 Feb 2026

A functional cell model using basophil activation test to study molecular mechanisms and biomarkers of response to omalizumab treatment in patients with asthma

in Molecular Innate Immunity

Boris Gole
Larisa Goričan
Gregor Jezernik
Mario Gorenjak
Anja Bizjak
Vojko Berce
Maja Skerbinjek Kavalar
Michael Kabesch
Erik Melén
Korneliusz Golebski

Frontiers in Immunology

doi 10.3389/fimmu.2026.1744735

Original Research

Published on 25 Aug 2022

Anticancer potential of mebendazole against chronic myeloid leukemia: in silico and in vitro studies revealed new insights about the mechanism of action

in Pharmacology of Anti-Cancer Drugs

Julio Paulino Daniel
Felipe Pantoja Mesquita
Emerson Lucena Da Silva
Pedro Filho Noronha de Souza
Luina Benevides Lima
Lais Lacerda Brasil de Oliveira
Maria Elisabete Amaral de Moraes
Caroline de Fátima Aquino Moreira-Nunes
Rommel Mario Rodríguez Burbano
Geancarlo Zanatta

Frontiers in Pharmacology

doi 10.3389/fphar.2022.952250

9,273 views
9 citations

Review

Published on 14 Jan 2025

Multiplex basophil activation tests for allergy diagnosis: present and future applications

in Allergy Diagnosis

Ana Koren
Peter Korosec

Frontiers in Allergy

doi 10.3389/falgy.2024.1515843

4,830 views
4 citations

Perspective

Published on 27 Feb 2023

OECD workshop consensus report: Ethical considerations with respect to human derived products, specifically human serum, in OECD test guidelines

in Regulatory Toxicology

Miriam N. Jacobs
Jan M. Bult
Kevin Cavanagh
Christophe Chesne
Nathalie Delrue
Jianan Fu
Emma Grange
Ingrid Langezaal
Dominika Misztela
Jenny Murray

Frontiers in Toxicology

doi 10.3389/ftox.2023.1140698

4,926 views
10 citations

Original Research

Published on 29 Aug 2025

Biomimetic hydrogel scaffolds for stimulating fibrotic responses: development of an in-vitro assay for implant material testing

in Biomaterials

VJ Spoddig
Rasika S. Murkar
Sascha Kopp
Heike Walles

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1628630

2,260 views
1 citation

Methods

Published on 27 Sep 2019

German Society of Biomechanics (DGfB) Young Investigator Award 2019: Proof-of-Concept of a Novel Knee Joint Simulator Allowing Rapid Motions at Physiological Muscle and Ground Reaction Forces

in Biomechanics

Florian Schall
Andreas M. Seitz
Steffen Hacker
Stefan van Drongelen
Sebastian I. Wolf
Anita Ignatius
Lutz Dürselen

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2019.00244

8,411 views
10 citations

Brief Research Report

Published on 07 Jul 2025

Unlocking liver physiology: comprehensive pathway maps for mechanistic understanding

in Computational Toxicology and Informatics

Luiz Ladeira
Anouk Verhoeven
Jonas van Ertvelde
Jian Jiang
Alessio Gamba
Julen Sanz-Serrano
Tamara Vanhaecke
Harm J. Heusinkveld
Ramiro Jover
Mathieu Vinken

Frontiers in Toxicology

doi 10.3389/ftox.2025.1619651

4,150 views
1 citation

Review

Published on 04 Mar 2022

Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka

in Ethnopharmacology

Kenny Kuchta
Kosuke Aritake
Yoshihiro Urade
Nguyen Huu Tung
Chun-Su Yuan
Yui Sasaki
Koichi Shimizu
Yukihiro Shoyama

Frontiers in Pharmacology

doi 10.3389/fphar.2021.779821

15,228 views
5 citations

Original Research

Published on 11 Apr 2024

OxyHbMeter—a novel bedside medical device for monitoring cell-free hemoglobin in the cerebrospinal fluid—proof of principle

in Diagnostic and Therapeutic Devices

Nikolaos Tachatos
Jan Folkard Willms
Michael Sebastian Gerlt
Kiran Kuruvithadam
Michael Hugelshofer
Kevin Akeret
Jeremy Deuel
Emanuela Keller
Marianne Schmid Daners

Frontiers in Medical Technology

doi 10.3389/fmedt.2024.1274058

2,804 views
2 citations

Original Research

Published on 16 Aug 2022

Complete genome sequencing of a Tequintavirus bacteriophage with a broad host range against Salmonella Abortus equi isolates from donkeys

in Phage Biology

Wenhua Liu
Letian Han
Peng Song
Huzhi Sun
Can Zhang
Ling Zou
Jiaqi Cui
Qiang Pan
Huiying Ren

Frontiers in Microbiology

doi 10.3389/fmicb.2022.938616

4,377 views
10 citations

Articles

Cell Culture Based in vitro Test Systems for Anticancer Drug Screening

Advancing chemical safety assessment through an omics-based characterization of the test system-chemical interaction

SRC is a potential target of Arctigenin in treating triple-negative breast cancer: based on machine learning algorithms, molecular modeling and in Vitro test

Aloe Polysaccharides Inhibit Influenza A Virus Infection—A Promising Natural Anti-flu Drug

New approach methods to improve human health risk assessment of thyroid hormone system disruption–a PARC project

Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

A functional cell model using basophil activation test to study molecular mechanisms and biomarkers of response to omalizumab treatment in patients with asthma

Anticancer potential of mebendazole against chronic myeloid leukemia: in silico and in vitro studies revealed new insights about the mechanism of action

Multiplex basophil activation tests for allergy diagnosis: present and future applications

OECD workshop consensus report: Ethical considerations with respect to human derived products, specifically human serum, in OECD test guidelines

Biomimetic hydrogel scaffolds for stimulating fibrotic responses: development of an in-vitro assay for implant material testing

German Society of Biomechanics (DGfB) Young Investigator Award 2019: Proof-of-Concept of a Novel Knee Joint Simulator Allowing Rapid Motions at Physiological Muscle and Ground Reaction Forces

Unlocking liver physiology: comprehensive pathway maps for mechanistic understanding

Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka

OxyHbMeter—a novel bedside medical device for monitoring cell-free hemoglobin in the cerebrospinal fluid—proof of principle

Complete genome sequencing of a Tequintavirus bacteriophage with a broad host range against Salmonella Abortus equi isolates from donkeys