Injection Pain | List of Frontiers open access articles

Clinical Trial

Published on 16 May 2025

Effect of ciprofol compared with propofol on hemodynamics in bronchoscope procedures during anesthetic induction: a randomized double-blind controlled study

in Intensive Care Medicine and Anesthesiology

Fang Chen
Fang Xing
Jiayu Huang
Junwen Zhu
Ye Jiang
Cheng Li

Frontiers in Medicine

doi 10.3389/fmed.2025.1545736

2,671 views
2 citations

Systematic Review

Published on 03 Feb 2026

Incidence of injection pain between ciprofol and propofol after induction of general anesthesia: a systematic review and meta-analysis of randomized controlled trials

in Intensive Care Medicine and Anesthesiology

Jinfang Zeng
Guowei Zhu
Jinjin Jian
Minmin Zhu

Frontiers in Medicine

doi 10.3389/fmed.2026.1749156

485 views

Review

Published on 25 Mar 2025

Pharmacological mechanism and clinical application of ciprofol

in Neuropharmacology

Jianshun Zhou
Lifeng Wang
Zhaoying Zhong
Lei Yuan
Jinhua Huang
Ping Zou
Xiaohui Cao
Donglan Peng
Baozhen Liao
Jianqiang Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572112

5,146 views
6 citations

Original Research

Published on 05 Sep 2023

The impact of SARS-Cov-2 infection on the periocular injection pain and hypersensitive reaction to botulinum toxin type A: results from clinical questionnaires

in Virus and Host

Xiangyu Liu
Yanli Tian
Chanyuan Jiang
Miao Dong
Ming Li
Hefeng Sun
Xuefeng Han
Facheng Li

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2023.1240303

4,868 views
1 citation

Clinical Trial

Published on 13 Oct 2022

Efficacy and safety of remimazolam besylate in bronchoscopy for adults: A multicenter, randomized, double-blind, positive-controlled clinical study

in Translational Pharmacology

Ying-Yong Zhou
Shu-Ting Yang
Kai-Ming Duan
Zhi-Hong Bai
Yun-Fei Feng
Qu-Lian Guo
Zhi-Gang Cheng
Hui Wu
Wang-Ning Shangguan
Xiao-Min Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1005367

8,224 views
46 citations

Clinical Trial

Published on 20 Sep 2022

Esketamine prevents propofol-induced injection pain: Randomized controlled trial

in Neuropharmacology

Chaozhi Xu
Xiaotang Wei
Cuiwen Zhang
Xiaofang Huang
Hongmeng Lan
Yanping Xu
Xiaoyan Wu
Fuping Li
Xuehai Guan

Frontiers in Pharmacology

doi 10.3389/fphar.2022.991559

5,338 views
29 citations

Systematic Review

Published on 15 Aug 2025

Comparison of ciprofol and propofol for endoscopic retrograde cholangio-pancreatography anesthesia: a systematic review and meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Kai Wu
Min Liao
Juan Deng
Yunfeng Yu
Yuman Yin
Xinyu Yang
Rong Yu
Zhenjie Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1592781

2,696 views

Systematic Review

Published on 06 Feb 2023

The use of remimazolam versus propofol for induction and maintenance of general anesthesia: A systematic review and meta-analysis

in Drugs Outcomes Research and Policies

Ching-Chung Ko
Kuo-Chuan Hung
Amina M. Illias
Chong-Chi Chiu
Chia-Hung Yu
Chien-Ming Lin
I-Wen Chen
Cheuk-Kwan Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1101728

28,851 views
83 citations

Original Research

Published on 24 Feb 2026

Ciprofol injection in patients receiving non-invasive positive pressure ventilation: a retrospective study

in Drugs Outcomes Research and Policies

DaLong Zhang
Lan Xiao
Xue Lv
ChenXi Ma
XiaoHan Zhang
XingGuo Niu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1745150

188 views

Original Research

Published on 09 Feb 2026

Effect of ciprofol on the incidence of hypotension during induction of general anesthesia in elderly patients undergoing total hip arthroplasty: single-center retrospective study

in Intensive Care Medicine and Anesthesiology

Jiaxi Zhu
Yun Chen
Ying Cao
Yicai Gan
Xingan Zhang
Bo Xu

Frontiers in Medicine

doi 10.3389/fmed.2026.1764580

295 views

Original Research

Published on 26 Apr 2019

Use Profile of Magnesium Sulfate in Anesthesia in Brazil

in Drugs Outcomes Research and Policies

Ismar Lima Cavalcanti
Fernando Lopes Tavares de Lima
Mario Jorge Sobreira da Silva
Rubens Antunes da Cruz Filho
Estêvão Luiz Carvalho Braga
Nubia Verçosa

Frontiers in Pharmacology

doi 10.3389/fphar.2019.00429

11,556 views
18 citations

Clinical Trial

Published on 27 Nov 2023

The median effective dose of propofol combined with butorphanol during artificial abortion: a randomized controlled trial

in Intensive Care Medicine and Anesthesiology

Yuling Zheng
Jinping Huang
Ying Mai
Xiaoling Li
Zhongqi Zhang

Frontiers in Medicine

doi 10.3389/fmed.2023.1226495

2,298 views
1 citation

Original Research

Published on 10 Sep 2025

Safety and efficacy evaluation of low-dose of esketamine combined with propofol for painless gastroscopy: a single-center, randomized, double-blind, parallel controlled clinical trial

in Intensive Care Medicine and Anesthesiology

Rong-sen Gu
Xiao-Yu Zhuang
Shao-Ping Wu
Xiao-Yu Huang
Zhi-yuan Lin
Yong-Fa Zhang

Frontiers in Medicine

doi 10.3389/fmed.2025.1606134

2,186 views

Clinical Trial

Published on 09 May 2023

Evaluating efficacy and safety of sub-anesthetic dose esketamine as an adjuvant to propofol/remifentanil analgosedation and spontaneous respiration for children flexible fibreoptic bronchoscopy: a prospective, double-blinded, randomized, and placebo-controlled clinical trial

in Neuropharmacology

Yu Zhong
Min Jiang
Yunshi Wang
Tingting Su
Yuanzhi Lv
Zhiqing Fan
Hengyi Ning
Yilan Yang
Yanhua Chen
Yubo Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1184663

8,579 views
28 citations

Original Research

Published on 05 Oct 2022

Safety and efficacy of remimazolam besylate in patients undergoing colonoscopy: A multicentre, single-blind, randomized, controlled, phase Ⅲ trial

in Gastrointestinal and Hepatic Pharmacology

Ximei Wang
Xiaolei Hu
Nianyue Bai
Lie Li
Min Zhang
Zhigang Cheng
Qulian Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2022.900723

6,205 views
38 citations

Clinical Trial

Published on 02 Sep 2022

Moderate sedation by total intravenous remimazolam-alfentanil vs. propofol-alfentanil for third molar extraction: A prospective randomized controlled trial

in Intensive Care Medicine and Anesthesiology

Nan Zhao
Jie Zeng
Lin Fan
Jing Wang
Chao Zhang
SiHai Zou
Bi Zhang
Kai Li
Cong Yu

Frontiers in Medicine

doi 10.3389/fmed.2022.950564

6,657 views
24 citations

Articles

Effect of ciprofol compared with propofol on hemodynamics in bronchoscope procedures during anesthetic induction: a randomized double-blind controlled study

Incidence of injection pain between ciprofol and propofol after induction of general anesthesia: a systematic review and meta-analysis of randomized controlled trials

Pharmacological mechanism and clinical application of ciprofol

The impact of SARS-Cov-2 infection on the periocular injection pain and hypersensitive reaction to botulinum toxin type A: results from clinical questionnaires

Efficacy and safety of remimazolam besylate in bronchoscopy for adults: A multicenter, randomized, double-blind, positive-controlled clinical study

Esketamine prevents propofol-induced injection pain: Randomized controlled trial

Comparison of ciprofol and propofol for endoscopic retrograde cholangio-pancreatography anesthesia: a systematic review and meta-analysis

The use of remimazolam versus propofol for induction and maintenance of general anesthesia: A systematic review and meta-analysis

Ciprofol injection in patients receiving non-invasive positive pressure ventilation: a retrospective study

Effect of ciprofol on the incidence of hypotension during induction of general anesthesia in elderly patients undergoing total hip arthroplasty: single-center retrospective study

Use Profile of Magnesium Sulfate in Anesthesia in Brazil

The median effective dose of propofol combined with butorphanol during artificial abortion: a randomized controlled trial

Safety and efficacy evaluation of low-dose of esketamine combined with propofol for painless gastroscopy: a single-center, randomized, double-blind, parallel controlled clinical trial

Evaluating efficacy and safety of sub-anesthetic dose esketamine as an adjuvant to propofol/remifentanil analgosedation and spontaneous respiration for children flexible fibreoptic bronchoscopy: a prospective, double-blinded, randomized, and placebo-controlled clinical trial

Safety and efficacy of remimazolam besylate in patients undergoing colonoscopy: A multicentre, single-blind, randomized, controlled, phase Ⅲ trial

Moderate sedation by total intravenous remimazolam-alfentanil vs. propofol-alfentanil for third molar extraction: A prospective randomized controlled trial