Intrathecal Immunoglobulin | List of Frontiers open access articles

Mini Review

Published on 15 Mar 2019

Impact of the McDonald Criteria 2017 on Early Diagnosis of Relapsing-Remitting Multiple Sclerosis

in Multiple Sclerosis and Neuroimmunology

Philipp Schwenkenbecher
Ulrich Wurster
Franz Felix Konen
Stefan Gingele
Kurt-Wolfram Sühs
Mike P. Wattjes
Martin Stangel
Thomas Skripuletz

Frontiers in Neurology

doi 10.3389/fneur.2019.00188

29,197 views
80 citations

Original Research

Published on 17 Feb 2026

Kappa free light chain index in CSF diagnostics: the impact of different immunoglobulin isotypes

in Multiple Sclerosis and Neuroimmunology

Martin Schmidauer
Klaus Berek
Michael Auer
Franziska Di Pauli
Fabian Föttinger
Nik Krajnc
Florian Deisenhammer
Gabriel Bsteh
Janette Walde
Harald Hegen

Frontiers in Immunology

doi 10.3389/fimmu.2026.1747659

381 views

Brief Research Report

Accepted on 26 Feb 2026

Kappa free light chains in cerebrospinal fluid to detect inflammation - results from a multicentric prospective real-world study

in Multiple Sclerosis and Neuroimmunology

Marie Suesse
Malte Johannes Hannich
Felix Lottermoser
Stefan Gross
Kathrin Budde
Irena Crnkovic-mertens
Margot Thiaucourt
Markus Roser
Franz Felix Konen
Thomas Skripuletz

Frontiers in Immunology

Case Report

Published on 10 Dec 2021

Case Report: HSV-2 Encephalitis Presenting With Chorea; Effects of Infection Alone or Combination of Infection and Autoimmunity?

in Multiple Sclerosis and Neuroimmunology

Michael Kolesnik
Ahmad A. Ballout
Natasha Hameed
Souhel Najjar

Frontiers in Neurology

doi 10.3389/fneur.2021.790514

4,851 views
5 citations

Original Research

Published on 11 Aug 2021

Evaluation of Kappa Index as a Tool in the Diagnosis of Multiple Sclerosis: Implementation in Routine Screening Procedure

in Multiple Sclerosis and Neuroimmunology

Carmen Teresa Sanz Diaz
Silvia de las Heras Flórez
Mercedes Carretero Perez
Miguel Ángel Hernández Pérez
Vicente Martín García

Frontiers in Neurology

doi 10.3389/fneur.2021.676527

8,852 views
33 citations

Original Research

Published on 29 Mar 2019

CSF Free Light Chains as a Marker of Intrathecal Immunoglobulin Synthesis in Multiple Sclerosis: A Blood-CSF Barrier Related Evaluation in a Large Cohort

in Multiple Sclerosis and Neuroimmunology

Makbule Senel
Fatemeh Mojib-Yezdani
Ulrike Braisch
Franziska Bachhuber
Jan Lewerenz
Albert C. Ludolph
Markus Otto
Hayrettin Tumani

Frontiers in Immunology

doi 10.3389/fimmu.2019.00641

9,420 views
56 citations

Original Research

Published on 15 Jun 2023

Clinical associations and characteristics of the polyspecific intrathecal immune response in elderly patients with non-multiple sclerosis chronic autoimmune-inflammatory neurological diseases – a retrospective cross-sectional study

in Multiple Sclerosis and Neuroimmunology

Felix Brauchle
Daniel Rapp
Makbule Senel
André Huss
Jens Dreyhaupt
Veronika Klose
Marie Süße
Klarissa Hanja Stürner
Frank Leypoldt
Hayrettin Tumani

Frontiers in Neurology

doi 10.3389/fneur.2023.1193015

3,767 views
4 citations

Original Research

Published on 10 Aug 2022

Increased intrathecal neurofilament light and immunoglobulin M predict severe disability in relapsing-remitting multiple sclerosis

in Multiple Sclerosis and Neuroimmunology

Igal Rosenstein
Sofia Rasch
Markus Axelsson
Lenka Novakova
Kaj Blennow
Henrik Zetterberg
Jan Lycke

Frontiers in Immunology

doi 10.3389/fimmu.2022.967953

3,501 views
9 citations

Original Research

Published on 03 May 2024

Evolution of peripheral nerve changes in early multiple sclerosis—a longitudinal MR neurography study

in Applied Neuroimaging

Olivia Foesleitner
Jennifer C. Hayes
Markus Weiler
Georges Sam
Brigitte Wildemann
Wolfgang Wick
Martin Bendszus
Sabine Heiland
Laura Bettina Jäger

Frontiers in Neurology

doi 10.3389/fneur.2024.1335408

3,250 views

Original Research

Published on 07 Mar 2022

High Levels of Cerebrospinal Fluid Kappa Free Light Chains Relate to IgM Intrathecal Synthesis and Might Have Prognostic Implications in Relapsing Multiple Sclerosis

in Multiple Sclerosis and Neuroimmunology

Jéssica Castillo-Villalba
Sara Gil-Perotín
Raquel Gasque-Rubio
Laura Cubas-Nuñez
Sara Carratalà-Boscà
Carmen Alcalá
Carlos Quintanilla-Bordás
Francisco Pérez-Miralles
Cristina Ferrer
Antonio Cañada Martínez

Frontiers in Immunology

doi 10.3389/fimmu.2022.827738

9,219 views
21 citations

Original Research

Published on 10 Sep 2015

Immunological findings in psychotic syndromes: a tertiary care hospital's CSF sample of 180 patients

in Brain Health and Clinical Neuroscience

Dominique Endres
Evgeniy Perlov
Annette Baumgartner
Tilman Hottenrott
Rick Dersch
Oliver Stich
Ludger Tebartz Van Elst

Frontiers in Human Neuroscience

doi 10.3389/fnhum.2015.00476

12,021 views
103 citations

Original Research

Published on 16 Oct 2020

Cerebrospinal Fluid IgM Levels in Association With Inflammatory Pathways in Multiple Sclerosis Patients

in Cellular Neuropathology

Roberta Magliozzi
Valentina Mazziotti
Luigi Montibeller
Anna I. Pisani
Damiano Marastoni
Agnese Tamanti
Stefania Rossi
Francesco Crescenzo
Massimiliano Calabrese

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2020.569827

10,863 views
14 citations

Articles

Impact of the McDonald Criteria 2017 on Early Diagnosis of Relapsing-Remitting Multiple Sclerosis

Kappa free light chain index in CSF diagnostics: the impact of different immunoglobulin isotypes

Kappa free light chains in cerebrospinal fluid to detect inflammation - results from a multicentric prospective real-world study

Case Report: HSV-2 Encephalitis Presenting With Chorea; Effects of Infection Alone or Combination of Infection and Autoimmunity?

Evaluation of Kappa Index as a Tool in the Diagnosis of Multiple Sclerosis: Implementation in Routine Screening Procedure

CSF Free Light Chains as a Marker of Intrathecal Immunoglobulin Synthesis in Multiple Sclerosis: A Blood-CSF Barrier Related Evaluation in a Large Cohort

Clinical associations and characteristics of the polyspecific intrathecal immune response in elderly patients with non-multiple sclerosis chronic autoimmune-inflammatory neurological diseases – a retrospective cross-sectional study

Increased intrathecal neurofilament light and immunoglobulin M predict severe disability in relapsing-remitting multiple sclerosis

Evolution of peripheral nerve changes in early multiple sclerosis—a longitudinal MR neurography study

High Levels of Cerebrospinal Fluid Kappa Free Light Chains Relate to IgM Intrathecal Synthesis and Might Have Prognostic Implications in Relapsing Multiple Sclerosis

Immunological findings in psychotic syndromes: a tertiary care hospital's CSF sample of 180 patients

Cerebrospinal Fluid IgM Levels in Association With Inflammatory Pathways in Multiple Sclerosis Patients