Lysosomal Proteases | List of Frontiers open access articles

Original Research

Published on 22 Aug 2025

Viral replication modulated by hallmark conformational ensembles: how AlphaFold-predicted features of RdRp folding dynamics combined with intrinsic disorder-mediated function enable RNA virus discovery

in Systems Virology

Rachid Tahzima
Justine Charon
Adrian Diaz
Kris De Jonghe
Sebastien Massart
Thierry Michon
Wim Vranken

Frontiers in Virology

doi 10.3389/fviro.2025.1501616

525 views

Original Research

Published on 22 Aug 2025

Exploring the protective mechanisms of the yunpi jiedu tongluo qushi decoction on methotrexate-induced reproductive damage in male rats based on Nrf2/HO-1 signaling pathway

in Cell Death and Survival

Wu Chen
Min Chen
Dian-Ming Li
Wei-Man Shi
Min Zhang
Zhi-Yu Li
Lin Huang
Cheng-Ping Wen
Qiao Wang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1626955

367 views

Original Research

Published on 22 Aug 2025

Multi-omic insights into mitochondrial dysfunction and prostatic disease: evidence from transcriptomics, proteomics, and methylomics

in Computational Genomics

Binbin Gong
Feixiang Yang
Ning Zhang
Zhengyang Wu
Tianrui Liu
Kun Wang
Xiangyu Zhang
Yangyang Zhang
Zhengyao Song
Chaozhao Liang

Frontiers in Genetics

doi 10.3389/fgene.2025.1609933

528 views

Systematic Review

Published on 22 Aug 2025

Facilitating or hindering learning - a meta-analysis of acceleration on video learning

in Educational Psychology

Guan Huang
Yixuan Du
Hairu Yang

Frontiers in Psychology

doi 10.3389/fpsyg.2025.1427609

473 views

General Commentary

Published on 22 Aug 2025

Commentary: Synergistic treatment of sodium propionate and Sishen Pill for diarrhea mice with kidney-yang deficiency syndrome

in Intestinal Microbiome

Zilin Zhao
Hejia Wan
Xiaohui Liu

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1641826

622 views

Original Research

Published on 22 Aug 2025

Simultaneous inactivation of antibiotic-resistant bacteria and degradation of antibiotic-resistant genes in alkalised human urine

in Antimicrobials, Resistance and Chemotherapy

Natnael Demissie
Annika Nordin
Prithvi Simha
Isis Conroy
He Sun
Anna Schnürer
Björn Vinnerås
Adey Desta

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1605625

783 views

Review

Published on 22 Aug 2025

Restless legs syndrome and growing pains in childhood: understanding the link

in Pediatric Neurology

Alexandra E. V. Rosen
Fabiana Ursitti
Nausica Stella
Laura Papetti
Martina Proietti Checchi
Alessandra Voci
Luigi Mazzone
Massimiliano Valeriani
Romina Moavero

Frontiers in Neurology

doi 10.3389/fneur.2025.1603694

364 views

Original Research

Published on 22 Aug 2025

Cost-effective analysis of sugemalimab plus chemotherapy as first-line treatment for advanced gastric or gastroesophageal junction adenocarcinoma with PD-L1 CPS ≥5

in Health Economics

Yalan Zhang
Ying He
Ruijia Chen
Maojin You

Frontiers in Public Health

doi 10.3389/fpubh.2025.1604372

491 views

Original Research

Published on 22 Aug 2025

Impact of gold price, financial development, renewable energy, economic growth, urbanization, and environmental tax on environmental degradation

in Environmental Economics and Management

Prince Dorian Rivel Bambi
Jean Baptiste Bernard Pea-Assounga

Frontiers in Environmental Science

doi 10.3389/fenvs.2025.1631189

394 views

Systematic Review

Published on 22 Aug 2025

Potential therapeutic benefits of curcumin in depression or anxiety induced by chronic diseases: a systematic review of mechanistic and clinical evidence

in Ethnopharmacology

Jiyuan Yuan
Chao Pi
Hongping Shen
Bi Zhou
Yumeng Wei
Nathupakorn Dechsupa
Ling Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1638645

391 views

Original Research

Published on 22 Aug 2025

Modeling the effectiveness of Esperanza window traps as a complementary vector control strategy for achieving the community-wide elimination of onchocerciasis

in Tropical Disease Epidemiology and Ecology

Shakir Bilal
Morgan E. Smith
Swarnali Sharma
Wajdi Zaatour
Ken Newcomb
Thomas R. Unnasch
Edwin Michael

Frontiers in Tropical Diseases

doi 10.3389/fitd.2025.1626506

363 views

Case Report

Published on 22 Aug 2025

Case Report: Hypergonadotropic hypogonadism in an elite athlete with variant in FSH receptor gene—clinical and sports implications of proper diagnosis

in Pediatric Endocrinology

Monika Skrzypiec-Spring
Agnieszka Zubkiewicz-Kucharska
Magdalena Pasińska
Michał Rabijewski
Robert Śmigiel
Adam Szeląg

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1648940

350 views

Original Research

Published on 22 Aug 2025

Evaluating lung cancer screening disparities in an integrated healthcare system: barriers and opportunities

in Thoracic Oncology

Carmen Javier
Sheng-Fang Jiang
Jenna Philippe
Isabel Arana
Jeffrey B. Velotta

Frontiers in Oncology

doi 10.3389/fonc.2025.1601458

552 views

Original Research

Published on 22 Aug 2025

Determinants of vaccination coverage during the COVID-19 pandemic among children aged 12–23 months in southern Ethiopia: a cross-sectional study

in Children and Health

Tigist Enyew Gedamu
Anmut Assemie
Leyla Temam Aleye
Meskerem Teketel Woldemariam
Tsegaye Gebre Argago
Alula Seyum Buda

Frontiers in Pediatrics

doi 10.3389/fped.2025.1566443

429 views

Original Research

Published on 22 Aug 2025

Swiss national radon database: impact of building and environmental factors

in Environmental Health and Exposome

Joan F. Rey
Caterina Berlusconi
Luca Pampuri
Joëlle Goyette Pernot

Frontiers in Public Health

doi 10.3389/fpubh.2025.1625922

349 views

Original Research

Published on 22 Aug 2025

Effects of finger acupressure combined with lower limb rehabilitation training machine on stroke recovery

in Neurorehabilitation

Xiaoxue Liu
Feng Zhang
Yanhong Li
Jieqiong Zhao
Yatao Du
Qian Zhang
Weifang Li

Frontiers in Neurology

doi 10.3389/fneur.2025.1609815

319 views

Articles

Viral replication modulated by hallmark conformational ensembles: how AlphaFold-predicted features of RdRp folding dynamics combined with intrinsic disorder-mediated function enable RNA virus discovery

Exploring the protective mechanisms of the yunpi jiedu tongluo qushi decoction on methotrexate-induced reproductive damage in male rats based on Nrf2/HO-1 signaling pathway

Multi-omic insights into mitochondrial dysfunction and prostatic disease: evidence from transcriptomics, proteomics, and methylomics

Facilitating or hindering learning - a meta-analysis of acceleration on video learning

Commentary: Synergistic treatment of sodium propionate and Sishen Pill for diarrhea mice with kidney-yang deficiency syndrome

Simultaneous inactivation of antibiotic-resistant bacteria and degradation of antibiotic-resistant genes in alkalised human urine

Restless legs syndrome and growing pains in childhood: understanding the link

Cost-effective analysis of sugemalimab plus chemotherapy as first-line treatment for advanced gastric or gastroesophageal junction adenocarcinoma with PD-L1 CPS ≥5

Impact of gold price, financial development, renewable energy, economic growth, urbanization, and environmental tax on environmental degradation

Potential therapeutic benefits of curcumin in depression or anxiety induced by chronic diseases: a systematic review of mechanistic and clinical evidence

Modeling the effectiveness of Esperanza window traps as a complementary vector control strategy for achieving the community-wide elimination of onchocerciasis

Case Report: Hypergonadotropic hypogonadism in an elite athlete with variant in FSH receptor gene—clinical and sports implications of proper diagnosis

Evaluating lung cancer screening disparities in an integrated healthcare system: barriers and opportunities

Determinants of vaccination coverage during the COVID-19 pandemic among children aged 12–23 months in southern Ethiopia: a cross-sectional study

Swiss national radon database: impact of building and environmental factors

Effects of finger acupressure combined with lower limb rehabilitation training machine on stroke recovery