Phase I Study | List of Frontiers open access articles

Original Research

Published on 31 May 2012

A Phase I Study of Dasatinib with Concurrent Chemoradiation for Stage III Non-Small Cell Lung Cancer

in Radiation Oncology

Howard Safran
Thomas DiPetrillo
Humera Khurshid
Thomas Ng
Kalyan Mantripragada
Ariel Birnbaum
David Berz
Kathy Radie-Keane
Kimberly Perez
Maria Constantinou

Frontiers in Oncology

doi 10.3389/fonc.2012.00056

6,342 views
13 citations

Clinical Trial

Published on 04 Feb 2025

Phase I study of pembrolizumab in combination with ibrutinib for the treatment of unresectable or metastatic melanoma

in Cancer Immunity and Immunotherapy

Yuan Yao
Yiyi Yan
Vera J. Suman
Allan B. Dietz
Courtney L. Erskine
Anastasios Dimou
Svetomir N. Markovic
Robert R. McWilliams
Heather N. Montane
Matthew S. Block

Frontiers in Immunology

doi 10.3389/fimmu.2025.1491448

3,844 views

Clinical Trial

Published on 07 Jul 2025

A phase I study to evaluate the effect of high-dose carbidopa on levodopa pharmacokinetics

in Drug Metabolism and Transport

Akane Hayashi
Atsushi Hosomi
Shinsaku Kihara
Masato Nishi
Saori Torisawa
Yoshiumi Ouchi
Hidenori Takada
Junichi Enokizono

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1596139

3,186 views
1 citation

Original Research

Published on 21 Jun 2024

Exploring the pharmacokinetics and tolerability of cyclooxygenase inhibitor ampiroxicam: a phase I study on single and multiple oral doses

in Drug Metabolism and Transport

Pengfei Zhao
Ying Qi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1429971

2,754 views

Original Research

Published on 24 May 2024

Stereotactic central/core ablative radiation therapy: results of a phase I study of a novel strategy to treat bulky tumor

in Radiation Oncology

Jun Yang
Qiuxia Lu
Weihua Qi
Ryann D. Kolb
Lei Wang
Yuan Li
Sida Li
Yihui Lin
Jiayi Liu
Waleed Mourad

Frontiers in Oncology

doi 10.3389/fonc.2024.1364627

5,420 views
13 citations

Original Research

Accepted on 17 Feb 2026

Phase I Study of Niraparib with Radiotherapy for Treatment of Metastatic and Locally Advanced Invasive Carcinoma of the Cervix (NIVIX)

in Gynecological Oncology

Piyush Pathak
Eunji Jo
Susan Hilsenbeck
Matthew Anderson
Alfredo Echeverria
Shelly Sharma
Jan Sunde
Tracilyn Hall
Anthony Costales
Claire Hoppenot

Frontiers in Oncology

Original Research

Published on 19 Apr 2023

A phase I study to assess safety, pharmacokinetics, and pharmacodynamics of a vaginal insert containing tenofovir alafenamide and elvitegravir

in Virus and Host

Andrea R. Thurman
Louise A. Ouattara
Nazita Yousefieh
Peter L. Anderson
Lane R. Bushman
Xi Fang
Homaira Hanif
Meredith Clark
Onkar Singh
Gustavo F. Doncel

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2023.1130101

5,145 views
11 citations

Clinical Trial

Published on 02 Jun 2022

A Phase I Study of Locoregional High-Dose Autologous Natural Killer Cell Therapy With Hepatic Arterial Infusion Chemotherapy in Patients With Locally Advanced Hepatocellular Carcinoma

in Cancer Immunity and Immunotherapy

Woo Kyun Bae
Byung Chan Lee
Hyeon-Jong Kim
Je-Jung Lee
Ik-Joo Chung
Sung Bum Cho
Yang Seok Koh

Frontiers in Immunology

doi 10.3389/fimmu.2022.879452

17,610 views
56 citations

Original Research

Published on 13 Dec 2011

Phase I Study of Celecoxib with Concurrent Irinotecan, Cisplatin, and Radiation Therapy for Patients with Unresectable Locally Advanced Non-Small Cell Lung Cancer

in Thoracic Oncology

Ritsuko Komaki
Xiong Wei
Pamela K Allen
Zhongxing Liao
Luka Milas
James D Cox
Michael S O'Reilly
Joe Chang
Mary Frances McAleer
Melenda Jeter

Frontiers in Oncology

doi 10.3389/fonc.2011.00052

7,170 views
12 citations

Original Research

Published on 16 Jul 2021

Phase I Study to Assess Safety of Laser-Assisted Topical Administration of an Anti-TNF Biologic in Patients With Chronic Plaque-Type Psoriasis

in Dermatology

Martin Bauer
Edith Lackner
Peter Matzneller
Valentin Al Jalali
Sahra Pajenda
Vincent Ling
Christof Böhler
Werner Braun
Reinhard Braun
Maximilian Boesch

Frontiers in Medicine

doi 10.3389/fmed.2021.712511

3,832 views
9 citations

Brief Research Report

Published on 12 Oct 2021

Safety and Effectiveness of Cell Therapy in Neurodegenerative Diseases: Take-Home Messages From a Pilot Feasibility Phase I Study of Progressive Supranuclear Palsy

in Neurodegeneration

Rosaria Giordano
Margherita Canesi
Maurizio Isalberti
Giovanni Marfia
Rolando Campanella
Daniele Vincenti
Viviana Cereda
Alessandra Ranghetti
Chiara Palmisano
Ioannis Ugo Isaias

Frontiers in Neuroscience

doi 10.3389/fnins.2021.723227

6,771 views
3 citations

Original Research

Published on 11 Apr 2025

CMOEP regimen in the treatment of untreated peripheral T-cell lymphoma: a multicenter, single-arm, phase I study

in Cancer Immunity and Immunotherapy

Jingwei Yu
Xiuhua Sun
Guangxun Gao
Li Yu
Jiesong Wang
Lihua Qiu
Zhengzi Qian
Wei Li
Huilai Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1551723

3,973 views
2 citations

Original Research

Published on 06 Feb 2025

High and low dose radiotherapy combined with ICIs for MSS colorectal cancer patients with liver metastases: a phase I study (HaRyPOT)

in Cancer Immunity and Immunotherapy

Yuxuan Ding
Yong Feng
Yangfan Ye
Jiayi Shen
Chang Guo
Xia He
Liangjun Zhu
Lijun Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1503517

3,119 views
1 citation

Clinical Trial

Published on 16 Dec 2024

A phase I study using bortezomib (Velcade), cladribine, and rituximab in treating patients over 50 years old with mantle cell lymphoma

in Hematologic Malignancies

Jeffrey J. Pu
Kristin N. Berger
Chunlei Zheng
Nhan Do
David F. Claxton
W. Christopher Ehmann
Joseph J. Drabick
Haiquan Li
Thomas P. Loughran
Elliot M. Epner

Frontiers in Oncology

doi 10.3389/fonc.2024.1449401

2,549 views

Clinical Trial

Published on 26 Nov 2020

Long-Term Outcomes of a Phase I Study With UV1, a Second Generation Telomerase Based Vaccine, in Patients With Advanced Non-Small Cell Lung Cancer

in Vaccines and Molecular Therapeutics

Paal F. Brunsvig
Tormod Kyrre Guren
Marta Nyakas
Claudius H. Steinfeldt-Reisse
Wenche Rasch
Jon Amund Kyte
Hedvig Vidarsdotter Juul
Steinar Aamdal
Gustav Gaudernack
Else Marit Inderberg

Frontiers in Immunology

doi 10.3389/fimmu.2020.572172

10,294 views
38 citations

Clinical Trial

Published on 02 Mar 2018

Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma

in Cancer Immunity and Immunotherapy

Jessica Da Gama Duarte
Sagun Parakh
Miles C. Andrews
Katherine Woods
Anupama Pasam
Candani Tutuka
Simone Ostrouska
Jonathan M. Blackburn
Andreas Behren
Jonathan Cebon

Frontiers in Immunology

doi 10.3389/fimmu.2018.00411

16,774 views
60 citations

Articles

A Phase I Study of Dasatinib with Concurrent Chemoradiation for Stage III Non-Small Cell Lung Cancer

Phase I study of pembrolizumab in combination with ibrutinib for the treatment of unresectable or metastatic melanoma

A phase I study to evaluate the effect of high-dose carbidopa on levodopa pharmacokinetics

Exploring the pharmacokinetics and tolerability of cyclooxygenase inhibitor ampiroxicam: a phase I study on single and multiple oral doses

Stereotactic central/core ablative radiation therapy: results of a phase I study of a novel strategy to treat bulky tumor

Phase I Study of Niraparib with Radiotherapy for Treatment of Metastatic and Locally Advanced Invasive Carcinoma of the Cervix (NIVIX)

A phase I study to assess safety, pharmacokinetics, and pharmacodynamics of a vaginal insert containing tenofovir alafenamide and elvitegravir

A Phase I Study of Locoregional High-Dose Autologous Natural Killer Cell Therapy With Hepatic Arterial Infusion Chemotherapy in Patients With Locally Advanced Hepatocellular Carcinoma

Phase I Study of Celecoxib with Concurrent Irinotecan, Cisplatin, and Radiation Therapy for Patients with Unresectable Locally Advanced Non-Small Cell Lung Cancer

Phase I Study to Assess Safety of Laser-Assisted Topical Administration of an Anti-TNF Biologic in Patients With Chronic Plaque-Type Psoriasis

Safety and Effectiveness of Cell Therapy in Neurodegenerative Diseases: Take-Home Messages From a Pilot Feasibility Phase I Study of Progressive Supranuclear Palsy

CMOEP regimen in the treatment of untreated peripheral T-cell lymphoma: a multicenter, single-arm, phase I study

High and low dose radiotherapy combined with ICIs for MSS colorectal cancer patients with liver metastases: a phase I study (HaRyPOT)

A phase I study using bortezomib (Velcade), cladribine, and rituximab in treating patients over 50 years old with mantle cell lymphoma

Long-Term Outcomes of a Phase I Study With UV1, a Second Generation Telomerase Based Vaccine, in Patients With Advanced Non-Small Cell Lung Cancer

Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma