Pigr | List of Frontiers open access articles

Original Research

Published on 18 Nov 2022

Evolutionary analyses of polymeric immunoglobulin receptor (pIgR) in the mammals reveals an outstanding mutation rate in the lagomorphs

in Comparative Immunology

Fabiana Neves
Patrícia de Sousa-Pereira
José Melo-Ferreira
Pedro J. Esteves
Ana Pinheiro

Frontiers in Immunology

doi 10.3389/fimmu.2022.1009387

3,407 views
2 citations

Original Research

Published on 02 May 2025

PIGR predicts good clinical outcomes and plays a tumor suppressor role in the development of breast cancer

in Breast Cancer

Tengfei Jiang
Zhi Sun
Ke Dong
Qian Pu
Haidong Gao
Yanrong Lv
Peng Li
Guanghui Zhao

Frontiers in Oncology

doi 10.3389/fonc.2025.1439120

2,762 views
5 citations

Original Research

Published on 05 Aug 2022

Polymeric immunoglobulin receptor suppresses colorectal cancer through the AKT-FOXO3/4 axis by downregulating LAMB3 expression

in Gastrointestinal Cancers: Colorectal Cancer

Ding Zhang
Hao Huang
Ting Zheng
Lei Zhang
Binbin Cui
Yanlong Liu
Shiheng Tan
Liyuan Zhao
Tian Tian
Lijing Gao

Frontiers in Oncology

doi 10.3389/fonc.2022.924988

5,769 views
14 citations

Original Research

Published on 26 Jun 2025

Plasma polymeric immunoglobulin receptor exacerbates lung injury in Klebsiella pneumoniae-induced pneumosepsis

in Systems Immunology

Shuaiwei Wang
Hao Fu
Xiaoqing Li
Hongrui Xu
Yu Bai
Wenjun Jiang
Xiaozhe Cheng
Na Chen
Yijie Zhang
Wei Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624014

3,045 views

Original Research

Published on 19 Jul 2018

Polymeric Immunoglobulin Receptor Mediates Immune Excretion of Mucosal IgM–Antigen Complexes Across Intestinal Epithelium in Flounder (Paralichthys olivaceus)

in Mucosal Immunity

Xiuzhen Sheng
Xiaoyu Qian
Xiaoqian Tang
Jing Xing
Wenbin Zhan

Frontiers in Immunology

doi 10.3389/fimmu.2018.01562

5,659 views
47 citations

Original Research

Published on 21 May 2021

The Alteration of Salivary Immunoglobulin A in Autism Spectrum Disorders

in Molecular Psychiatry

Wuyi Gong
Yanan Qiao
Bosheng Li
Xiaoguo Zheng
Ruihuan Xu
Mingbang Wang
Xiaohui Mi
Yongming Li

Frontiers in Psychiatry

doi 10.3389/fpsyt.2021.669193

8,062 views
12 citations

Original Research

Published on 13 Apr 2022

EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice

in Mucosal Immunity

Zili Lei
Wanwan Liu
Ya Nie
Yanhong Yang
Guibin Chen
Li Huang
Huijuan Wu
Yuting Lei
Lei Chen
Qing Hu

Frontiers in Immunology

doi 10.3389/fimmu.2022.843378

5,671 views
10 citations

Review

Published on 02 Dec 2013

Stress modulates intestinal secretory immunoglobulin A

Rafael Campos-Rodríguez
Marycarmen Godínez-Victoria
Edgar Abarca-Rojano
Judtih Pacheco-Yepez
Humberto Reyna-Garfias
Reyna Elizabeth Barbosa-Cabrera
Maria Elisa Drago-Serrano

Frontiers in Integrative Neuroscience

doi 10.3389/fnint.2013.00086

34,404 views
112 citations

Original Research

Published on 06 Feb 2023

Single-cell RNA sequencing reveals the immune microenvironment and signaling networks in cystitis glandularis

in Inflammation

Tai Lai Zhou
Heng Xin Chen
Yin Zhao Wang
Si Jie Wen
Ping Hong Dao
Yu Hang Wang
Min Feng Chen

Frontiers in Immunology

doi 10.3389/fimmu.2023.1083598

6,730 views
6 citations

Review

Published on 10 Jun 2016

Immunoglobulin Transporting Receptors Are Potential Targets for the Immunity Enhancement and Generation of Mammary Gland Bioreactor

in Vaccines and Molecular Therapeutics

Xuemei Jiang
Jianjun Hu
Diraviyam Thirumalai
Xiaoying Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2016.00214

7,925 views
50 citations

Original Research

Published on 12 Aug 2024

The downregulation of tight junction proteins and pIgR in the colonic epithelium causes the susceptibility of EpCAM+/− mice to colitis and gut microbiota dysbiosis

in Cellular Biochemistry

Ya Nie
Ting Lin
Yanhong Yang
Wanwan Liu
Qing Hu
Guibin Chen
Li Huang
Huijuan Wu
Cunjie Kong
Zili Lei

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1442611

4,958 views
5 citations

Original Research

Published on 13 Jul 2021

Human Breast Milk Enhances Intestinal Mucosal Barrier Function and Innate Immunity in a Healthy Pediatric Human Enteroid Model

in Stem Cell Research

Gaelle Noel
Julie G. In
Jose M. Lemme-Dumit
Lauren R. DeVine
Robert N. Cole
Anthony L. Guerrerio
James D. Campbell
Olga Kovbasnjuk
Marcela F. Pasetti

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.685171

11,309 views
45 citations

Original Research

Published on 24 May 2019

IgA-Targeted Lactobacillus jensenii Modulated Gut Barrier and Microbiota in High-Fat Diet-Fed Mice

in Microbial Symbioses

Jin Sun
Ce Qi
Hualing Zhu
Qin Zhou
Hang Xiao
Guowei Le
Daozhen Chen
Renqiang Yu

Frontiers in Microbiology

doi 10.3389/fmicb.2019.01179

9,535 views
31 citations

Original Research

Published on 04 Jun 2021

Association of Inflammation-Related Gene Polymorphisms With Susceptibility and Radiotherapy Sensitivity in Head and Neck Squamous Cell Carcinoma Patients in Northeast China

in Radiation Oncology

Ying Li
Li Zhu
Hongmin Yao
Ye Zhang
Xiangyu Kong
Liping Chen
Yingqiu Song
Anna Mu
Xia Li

Frontiers in Oncology

doi 10.3389/fonc.2021.651632

3,583 views
9 citations

Original Research

Published on 05 Feb 2026

Latilactobacillus sakei strains protect crucian carp against Aeromonas hydrophila–induced intestinal injury in an oral challenge model

in Nutritional Immunology

Yan Zhao
Ruizhe Li
Ting Zhu
Huanhuan Hu
Guanghui An
Zhangheng Ren
Jie Cui
Jinchi Jiang

Frontiers in Nutrition

doi 10.3389/fnut.2026.1768111

1,471 views

Original Research

Published on 17 Nov 2022

Proteomics analysis reveals novel insights into the mechanism of hepatotoxicity induced by Tripterygium wilfordii multiglycoside in mice

in Ethnopharmacology

Yingying Miao
Qin Zhang
Zihang Yuan
Jie Wang
Yunxia Xu
Yuanyuan Chai
Min Du
Qinwei Yu
Luyong Zhang
Zhenzhou Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1032741

3,572 views
3 citations

Articles

Evolutionary analyses of polymeric immunoglobulin receptor (pIgR) in the mammals reveals an outstanding mutation rate in the lagomorphs

PIGR predicts good clinical outcomes and plays a tumor suppressor role in the development of breast cancer

Polymeric immunoglobulin receptor suppresses colorectal cancer through the AKT-FOXO3/4 axis by downregulating LAMB3 expression

Plasma polymeric immunoglobulin receptor exacerbates lung injury in Klebsiella pneumoniae-induced pneumosepsis

Polymeric Immunoglobulin Receptor Mediates Immune Excretion of Mucosal IgM–Antigen Complexes Across Intestinal Epithelium in Flounder (Paralichthys olivaceus)

The Alteration of Salivary Immunoglobulin A in Autism Spectrum Disorders

EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice

Stress modulates intestinal secretory immunoglobulin A

Single-cell RNA sequencing reveals the immune microenvironment and signaling networks in cystitis glandularis

Immunoglobulin Transporting Receptors Are Potential Targets for the Immunity Enhancement and Generation of Mammary Gland Bioreactor

The downregulation of tight junction proteins and pIgR in the colonic epithelium causes the susceptibility of EpCAM+/− mice to colitis and gut microbiota dysbiosis

Human Breast Milk Enhances Intestinal Mucosal Barrier Function and Innate Immunity in a Healthy Pediatric Human Enteroid Model

IgA-Targeted Lactobacillus jensenii Modulated Gut Barrier and Microbiota in High-Fat Diet-Fed Mice

Association of Inflammation-Related Gene Polymorphisms With Susceptibility and Radiotherapy Sensitivity in Head and Neck Squamous Cell Carcinoma Patients in Northeast China

Latilactobacillus sakei strains protect crucian carp against Aeromonas hydrophila–induced intestinal injury in an oral challenge model

Proteomics analysis reveals novel insights into the mechanism of hepatotoxicity induced by Tripterygium wilfordii multiglycoside in mice