Preclinical Stage | List of Frontiers open access articles

Original Research

Published on 02 Oct 2025

Integrative genetic and multi-omics analysis reveals the interleukin-6 receptor’s role in recurrent spontaneous abortion

in Cytokines and Soluble Mediators in Immunity

Weixu Ma
Zhongjia Gu
Qiwang Lin
Mingzhu Cao
Junmin Zhong
Xin Li
Hongyan Li
Yue Lin
Han Lin
Mengchang Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659251

588 views

Original Research

Published on 02 Oct 2025

Analyses of haplotypes of TLR2 and TLR3 genes for COVID-19 prognosis in a cohort of professionals who worked in the first pandemic wave in Belém-PA, Brazil

in Computational Genomics

Marcos Jessé Abrahão Silva
Luiza Raquel Tapajós Figueira
Daniele Melo Sardinha
Eliete Costa da Cruz
Natasha Cristina Oliveira Andrade
Sebastião Kauã De Sousa Bispo
Thiago Augusto Ferreira Dos Anjos
Everaldina Cordeiro Dos Santos
Ana Judith Pires Garcia
Luana Nepomuceno Gondim Costa Lima

Frontiers in Genetics

doi 10.3389/fgene.2025.1659269

483 views

Original Research

Published on 02 Oct 2025

A predictive model for upper gastrointestinal bleeding in patients with acute myocardial infarction complicated by cardiogenic shock during hospitalization

in Intensive Care Cardiovascular Medicine

Fei Dong
Ying Zhou
Yufei Zhao
Yunqiang Zhang
Haiqing Liang
Yu Song
Rui Jing

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1662067

733 views

Original Research

Published on 02 Oct 2025

Time-series transcriptomics and alternative splicing analysis of embryonic development of the asian honeybee (Apis cerana)

in Livestock Genomics

Xiang Ding
Zukai Liu
Linsen Ou
Zhihui Wang
Qian Xu
Runlang Su

Frontiers in Genetics

doi 10.3389/fgene.2025.1665548

1,270 views

Original Research

Published on 02 Oct 2025

Pelubiprofen and Shinbaro: a therapeutic approach for osteoarthritis in a murine medial meniscus destabilization model

in Experimental Pharmacology and Drug Discovery

Jin Young Hong
Hyunseong Kim
Hyun Kim
Wan-Jin Jeon
Changhwan Yeo
Junseon Lee
Yoon Jae Lee
In-Hyuk Ha

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1665393

293 views

Hypothesis and Theory

Published on 02 Oct 2025

Detached self-observation as a developmental catalyst: theoretical insights from dynamical systems thinking, cultural mediation, and contemplative practice

in Consciousness Research

Lea Loncar
Charlotte Fiskum

Frontiers in Psychology

doi 10.3389/fpsyg.2025.1659774

748 views

Original Research

Published on 02 Oct 2025

Study on the application of prone and supine lung recruitment maneuvers in the treatment of atelectasis after minimally invasive direct coronary artery bypass surgery

in Cardiovascular Surgery

Yue Xin
Zelin Meng
Zhou Fu
Pixiong Su

Frontiers in Surgery

doi 10.3389/fsurg.2025.1665139

484 views

Original Research

Published on 02 Oct 2025

Coixol ameliorates dopaminergic neurodegeneration by inhibiting neuroinflammation and protecting mitochondrial function

in Ethnopharmacology

Shuo Yang
Jiaxi Han
Miao Xue
Yiming Zhang
Aohan Yan
Xiyu Gao
Jiangmei He
Xiaojia Sun
Shoupeng Fu
Dianfeng Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657910

643 views

Editorial

Published on 02 Oct 2025

Editorial: Impacts of climate change on seaweeds

in Global Change and the Future Ocean

Christopher E. Cornwall
Denisa M. Berbece
Caitlin O. Blain
Maggie D. Johnson
Samuel Starko

Frontiers in Marine Science

doi 10.3389/fmars.2025.1702410

1,707 views

Editorial

Published on 02 Oct 2025

Editorial: Immunometabolic alterations linked to affective disorders and other mental illnesses

in Psychopathology

Yolanda Sánchez-Carro
Pilar López-García
Alejandro de la Torre-Luque

Frontiers in Psychology

doi 10.3389/fpsyg.2025.1699733

3,466 views

Editorial

Published on 02 Oct 2025

Editorial: New avenues for the development of advanced immunotherapies: capitalizing on studies of the B and T cell receptor repertoire

in Cancer Immunity and Immunotherapy

Fabio Nicolini
Mar Naranjo Gomez
Mireia Pelegrin
Anna De Lucia
Lucia Mazzotti
Massimiliano Mazza

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693587

292 views

Mini Review

Published on 02 Oct 2025

The critical role of NAT10-mediated N4-acetylcytidine modification in tumor immunity

in Cancer Immunity and Immunotherapy

Chunhong Li
Xiulin Jiang
YingDong Jia
Qiang Zhou
Yixiao Yuan
Qiang Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1695495

234 views

Original Research

Published on 02 Oct 2025

The relationship between structural characteristics of long-term care institutions and their initial operating budgets

in Aging and Public Health

Xiaojing Wang
Peter C. Coyte

Frontiers in Public Health

doi 10.3389/fpubh.2025.1669451

314 views

Original Research

Published on 02 Oct 2025

Ibrutinib combined with rituximab and high-dose methotrexate in newly diagnosed primary CNS diffuse large B-cell lymphoma: a pilot study with long-term follow-up

in Hematologic Malignancies

Yixian Guo
Yongzhi Shan
Yueshan Piao
Xiaoli Chang
Dongmei Zou
Qiang Ma
Yukui Wei
Geng Xu
Yaming Wang
Dandan Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1669385

1,333 views

Brief Research Report

Published on 02 Oct 2025

Evaluating the impact of immune checkpoint inhibitors on liver steatosis and function: a retrospective cohort analysis

in Cancer Immunity and Immunotherapy

Sophie K. Schellhammer
Jessica Quintos Day
Run Fan
Fei Ye
Virginia Planz
Douglas B. Johnson

Frontiers in Oncology

doi 10.3389/fonc.2025.1683982

694 views

Original Research

Published on 02 Oct 2025

AU-super: superpixel scale optimization and training data augmentation strategy for hyperspectral image classification

in Image Analysis and Classification

Yiran Wang
Lingling Li
Mingming Xu
Shanwei Liu
Muhammad Yasir
Manuel Á. Aguilar
Fernando J. Aguilar

Frontiers in Remote Sensing

doi 10.3389/frsen.2025.1685140

477 views

Articles

Integrative genetic and multi-omics analysis reveals the interleukin-6 receptor’s role in recurrent spontaneous abortion

Analyses of haplotypes of TLR2 and TLR3 genes for COVID-19 prognosis in a cohort of professionals who worked in the first pandemic wave in Belém-PA, Brazil

A predictive model for upper gastrointestinal bleeding in patients with acute myocardial infarction complicated by cardiogenic shock during hospitalization

Time-series transcriptomics and alternative splicing analysis of embryonic development of the asian honeybee (Apis cerana)

Pelubiprofen and Shinbaro: a therapeutic approach for osteoarthritis in a murine medial meniscus destabilization model

Detached self-observation as a developmental catalyst: theoretical insights from dynamical systems thinking, cultural mediation, and contemplative practice

Study on the application of prone and supine lung recruitment maneuvers in the treatment of atelectasis after minimally invasive direct coronary artery bypass surgery

Coixol ameliorates dopaminergic neurodegeneration by inhibiting neuroinflammation and protecting mitochondrial function

Editorial: Impacts of climate change on seaweeds

Editorial: Immunometabolic alterations linked to affective disorders and other mental illnesses

Editorial: New avenues for the development of advanced immunotherapies: capitalizing on studies of the B and T cell receptor repertoire

The critical role of NAT10-mediated N4-acetylcytidine modification in tumor immunity

The relationship between structural characteristics of long-term care institutions and their initial operating budgets

Ibrutinib combined with rituximab and high-dose methotrexate in newly diagnosed primary CNS diffuse large B-cell lymphoma: a pilot study with long-term follow-up

Evaluating the impact of immune checkpoint inhibitors on liver steatosis and function: a retrospective cohort analysis

AU-super: superpixel scale optimization and training data augmentation strategy for hyperspectral image classification