ORIGINAL RESEARCH article
Front. Genet.
Sec. Computational Genomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1659269
Analyzes of Haplotypes of TLR2 and TLR3 genes for COVID-19 Prognosis in a Cohort of Professionals who Worked in the 1st Pandemic Wave in Belém-PA, Brazil
Provisionally accepted
Marcos Jessé Abrahão Silva1*
Luiza Raquel Tapajós Figueira2
Daniele Melo Sardinha2Natasha Cristina Oliveira Andrade2Sebastião Kauã De Sousa Bispo3
Thiago Augusto Ferreira Dos Anjos3Everaldina Cordeiro dos Santos2Ana Judith Pires Garcia3Luana Nepomuceno Gondim Costa Lima3- 1Universidade do Estado do Pará, Belem, Brazil
- 2Universidade do Estado do Para, Belém, Brazil
- 3Instituto Evandro Chagas, Ananindeua, Brazil
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COVID-19 is a multi-systemic disease caused by SARS-CoV-2 that can occasions several pulmonary illness according to the immunological contexts of the individual. Haplotypes comprehend Single Nucleotide Polymorphisms (SNPs) on candidate genes for diseases. TLR2 and TLR3 are genes located on human chromosome 4 (chr:4) and composite a haplotype that influence immune signaling and inflammatory pathways. The purpose of this article was to genetically analyze in silico a cohort of professionals from Belém-PA during the first wave of the pandemic using SNPs rs3804100, rs3775290 and rs3775291 on the human chr:4. This is a computacional genomic design using bioinformatic softwares and machine-learning technologies on epidemiological data of Sanger Sequencing data. Regarding the findings, none of the alleles formed by the haplotype showed statistical significance for symptomatology or disease severity. The haplotype block was not significant between the SNPs analyzed, despite a high permutation rate of alleles at the beginning of the variance of the individual genomic data. Then, TLR2-TLR3 haplotype (SNPs rs3804100, rs3775290 and rs3775291) showed little determination in the clinic of individuals with COVID-19 in Belém (Northern Brazil), which may indicate differences in collective genetic patterns and/or epigenetic influences compared to other more affected populations that have the same haplotype pattern.
Keywords: COVID-19, TLR2, TLR3, Brazil, Single nucleotide polymorphism
Received: 03 Jul 2025; Accepted: 15 Sep 2025.
Copyright: © 2025 Silva, Figueira, Sardinha, Andrade, Bispo, Augusto Ferreira Dos Anjos, dos Santos, Garcia and Lima. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Marcos Jessé Abrahão Silva, jesseabrahao10@gmail.com
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